GLPBio

CD73

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CD73 (Ecto-5′-nucleotidase), a component of the purinergic signaling pathway, is a 70-kD glycosylphosphatidylinositol-anchored cell surface protein encoded by the NT5E gene.

CD73 has both enzymatic and non-enzymatic functions in cells. As a nucleotidase, CD73 catalyzes the hydrolysis of AMP into adenosine and phosphate, and CD73-generated adenosine plays an important role in tumor immunoescape. CD73 plays a crucial role in switching on adenosinergic signaling. CD73 also functions as a signal and adhesive molecule that can regulate cell interaction with extracellular matrix components, such as laminin and fibronectin, to mediate the invasive and metastatic properties of cancers. Both the enzymatic and non-enzymatic functions of CD73 are involved in cancer-associated processes and are not completely independent of each other.

Overexpression of CD73 is associated with resistance to antitumor agents. Knockdown of CD73 inhibits in vitro cell growth, cell cycle progression and cell migration in many cancers. CD73 and its associated pathways may be useful as therapeutic targets.

Products Related to CD73(15)

  • GC31914 structure
    GC31914CD73-IN-1
    CAS: 2132396-40-6
    Purity: >98.50%

    CD73-IN-1은 특허 WO 2017153952 A1, 실시예 80에서 추출한 암 치료에 사용할 수 있는 CD73의 억제제입니다.

  • GC32795 structure
    GC32795PSB-12379
    CAS: 1802226-78-3
    Purity: >99.50%

    뉴클레오티드 유사체인 PSB-12379는 Kis가 9.03nM(쥐) 및 2.21nM(인간)인 강력한 Ecto-5'-Nucleotidase(CD73) 억제제입니다.

  • GC36587 structure
    GC36587MethADP
    CAS: 3768-14-7
    Purity: >99.50%

    MethADP는 특정 CD73 억제제입니다.

  • GC36588 structure
    GC36588MethADP sodium salt
    CAS: 89016-30-8
    Purity: >98%

    MethADP(나트륨염)는 특정 CD73 억제제입니다.

  • GC62331 structure
    GC62331CD73-IN-3
    CAS: 2375815-63-5
    Purity: >99.50%

    CD73-IN-3은 강력한 CD73 억제제입니다(Calu6 인간 세포 분석에서 IC50=7.3 nM). 특허 WO2019168744 A1에서 추출한 실시예 2인 CD73-IN-3은 암 연구에 대한 잠재력이 있습니다.

  • GC62452 structure
    GC62452CD73-IN-4
    CAS: 2216764-29-1
    Purity: >99.50%

    CD73-IN-4는 인간 CD73에 대해 IC50이 2.6nM인 강력하고 선택적인 메틸렌포스폰산 CD73 억제제입니다.

  • GC62694 structure
    GC62694OP-5244
    CAS: 2381268-71-7
    Purity: >99.50%

    OP-5244는 IC50이 0.25nM인 강력한 경구 활성 억제제인 CD73입니다.

  • GC62695 structure
    GC62695OP-5244 sodium
    Purity: >98%

    OP-5244 나트륨은 0.25nM의 IC50으로 CD73의 강력한 경구 활성 억제제입니다.

  • GC65293 structure
    GC65293AB-680
    CAS: 2105904-82-1
    Purity: >98.00%

    AB-680은 CD73(외부 뉴클레오티다제)의 매우 강력하고 가역적이며 선택적인 억제제이며, hCD73에 대한 Ki가 4.9pM이고 관련 외부 뉴클레오티다제 CD39에 비해 10,000배 이상의 선택성을 나타냅니다. 항종양 활성.

  • GC65470 structure
    GC65470Oleclumab
    CAS: 1803176-05-7
    Purity: >98.00%

    올레클루맙(MEDI9447)은 CD73 기능을 억제하는 인간 IgG1Λ 항-CD73 모노클로날 항체입니다. 올레클루맙은 항종양 활성이 있습니다.

  • GC68344 structure
    GC68344Mupadolimab
    CAS: 2451856-97-4
    Purity: >98%
  • GC68346 structure
    GC68346Uliledlimab
    CAS: 2378407-27-1
    Purity: >98%
  • GC68386 structure
    GC68386CD73-IN-5
    CAS: 2412019-99-7
    Purity: >98%
  • GC69453 structure
    GC69453MethADP triammonium
    Purity: >99.00%

    MethADP (아데노신 5'-알파,베타-메틸렌디인수화물)트리암모늄은 CD73 억제제입니다. MethADP는 ATP-아데노신 경로 연구에 사용될 수 있습니다.

  • GC79353 structure
    GC793532,4-Dinitrobenzenesulfonic acid
    CAS: 89-02-1
    Purity: >98.00%

    2,4-Dinitrobenzenesulfonic acid (Compound 3) is a ecto-5'-Nucleotidase ( CD73 ) inhibitor with a K i value of 63 μM for human and 144 μM for rat.