>>Proteins>> Recombinant Proteins>> Superoxide Dismutase>>Chamazulene

Chamazulene (Synonyms: Dimethulene)

Catalog No.GC52081

천연 화합물인 Chamazulene은 류코트리엔 B4 형성의 항산화제 유형 억제제입니다.

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Chamazulene Chemical Structure

Cas No.: 529-05-5

Size 가격 재고 수량
1 mg
US$301.00
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5 mg
US$1,349.00
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10 mg
US$1,650.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Description of Chamazulene

Chamazulene is a terpene that has been found in chamomile (M. recutita) flowers and has anti-inflammatory and antioxidant activities.1 It reduces increases in matrix metalloproteinase-3 (MMP-3), MMP-9, COX-2, inducible nitric oxide synthase (iNOS), and p65 NF-κB levels in IL-1β-stimulated primary rat chondrocytes when used at a concentration of 10 µg/ml. Chamazulene (10 and 20 µg/ml) reduces IL-1β-induced production of malondialdehyde (MDA) and increases levels of superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) in primary rat chondrocytes. In vivo, chamazulene (25 and 50 mg/kg) reduces hind paw volume, serum levels of MDA, TNF-α, and IL-6, and cartilage erosion in a rat model of osteoarthritis induced by complete Freund’s adjuvant (CFA).

1.Ma, D., He, J., and He, D.Chamazulene reverses osteoarthritic inflammation through regulation of matrix metalloproteinases (MMPs) and NF-kβ pathway in in-vitro and in-vivo modelsBiosci. Biotechol. Biochem.84(2)402-410(2020)

Chemical Properties of Chamazulene

Cas No. 529-05-5 SDF
Synonyms Dimethulene
Canonical SMILES CCC1=CC=C(C)C2=CC=C(C)C2=C1
Formula C14H16 M.Wt 184.3
Solubility Ethanol: soluble,Water: very slightly soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Chamazulene

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 5.4259 mL 27.1297 mL 54.2594 mL
5 mM 1.0852 mL 5.4259 mL 10.8519 mL
10 mM 0.5426 mL 2.713 mL 5.4259 mL
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In vivo Formulation Calculator (Clear solution) of Chamazulene

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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