CKGGRAKDC (linear) TFA is an adipose tissue homing peptide. CKGGRAKDC (linear) TFA binds to vasculature-enriched prohibitin in adipose tissue to enable selective tissue targeting. CKGGRAKDC (linear) TFA can be used to selective delivery of cargos to adipose tissues [1].
In Vitro, CKGGRAKDC (linear) TFA promotes the selective enrichment of coupled liposome nanoparticles in adipose tissue and reduces their retention in non-adipose tissues[1].
References:
[1]. Chen K, et al. Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects. Nat Commun. 2022;13(1):7838. Published 2022 Dec 20.
In Vitro, CKGGRAKDC (linear) TFA promotes the selective enrichment of coupled liposome nanoparticles in adipose tissue and reduces their retention in non-adipose tissues[1].
References:
[1]. Chen K, et al. Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects. Nat Commun. 2022;13(1):7838. Published 2022 Dec 20.