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Gamma Secretase

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Gamma secretase (γ-secretase), a member of the intramembrane cleaving protease (i-CLiP) family, is a promiscuous di-aspartyl protease that catalyzes the regulated intramembrane proteolysis (RIP), in which substrate proteins are cleaved within their membrane-spanning domain. A functional γ-secretase is a multi-protein complex consisting of the catalytic component, presenilin (PSEN), and three protein cofactors, including nicastrin (NCT), anterior-pharynx defective-1 (APH1) and PSEN enhancer-2 (PEN2). So far, 90 substrates of γ-secretase have been identified, which are type-I transmembrane proteins, except for glutamate receptor GluR3, polycystin-1 and glucosaminyltransferase (GnT-V), and appear to function as signaling proteins regulating a wide variety of cellular events, such as Notch signaling pathway.

Products Related to Gamma Secretase(42)

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    GC10064Flurizan
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    A COX-inactive enantiomer of flurbiprofen

  • GC10998 structure
    GC10998PF-03084014
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    γ-secretase inhibitor

  • GC12096 structure
    GC12096Semagacestat (LY450139)
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    A pan γ-secretase inhibitor

  • GC12191 structure
    GC12191LY-411575
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    A γ-secretase inhibitor

  • GC12653 structure
    GC12653LY3039478
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    A Notch inhibitor

  • GC12659 structure
    GC12659Begacestat
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    An inhibitor of γ-secretase

  • GC12942 structure
    GC12942DAPT (GSI-IX)
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    Purity: >98.00%

    DAPT (GSI-IX)는 경구 활성 γ-시크레타제 억제제로 총 아밀로이드-β(Aβ) 및 Aβ42에 대한 IC₅₀ 값은 각각 115 nM 및 200 nM이다.

  • GC13099 structure
    GC13099BMS 299897
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    Purity: >98.50%

    A γ-secretase inhibitor

  • GC13619 structure
    GC13619JLK 6
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    Purity: >98%

    A protease inhibitor

  • GC13673 structure
    GC13673BMS-708163 (Avagacestat)
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    A potent inhibitor of γ-secretase

  • GC15059 structure
    GC15059Sulindac sulfide
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    Purity: >99.00%

    Sulindac sulfide는 γ42-secretase 활성에 대한 IC50이 20.2μM인 비경쟁적 γ-secretase 억제제입니다.

  • GC15364 structure
    GC15364L-685,458
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    Purity: >99.00%

    A γ-secretase inhibitor

  • GC15645 structure
    GC15645Compound W
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    Purity: >98%

    A Notch1 signaling modulator

  • GC15896 structure
    GC15896Z-Ile-Leu-aldehyde
    CAS: 161710-10-7
    Purity: >98.00%

    Z-Ile-Leu-aldehyde(Z-IL-CHO)는 γ-secretase 및 notch의 강력하고 경쟁력 있는 펩티드 알데히드 억제제입니다.

  • GC15899 structure
    GC15899MK-0752
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    Purity: >98.00%

    A potent inhibitor of γ-secretase

  • GC16197 structure
    GC16197RO4929097
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    Purity: >98.00%

    An inhibitor of γ-secretase

  • GC16431 structure
    GC16431MRK 560
    CAS: 677772-84-8
    Purity: >99.00%

    A potent inhibitor of γ-secretase

  • GC17671 structure
    GC17671YO-01027 (Dibenzazepine, DBZ)
    CAS: 209984-56-5
    Purity: >98.00%

    YO-01027 (Dibenzazepine, DBZ)은 γ-시크레타제 억제제로APPL과 Notch 절단에 대한 IC50 값은 각각 2.64±0.30과 2.92±0.22Nm이다.

  • GC17791 structure
    GC17791LY2811376
    CAS: 1194044-20-6
    Purity: >99.50%

    A BACE1 inhibitor

  • GC19290 structure
    GC19290PF-3084014
    CAS: 1290543-63-3
    Purity: >98.00%

    PF-3084014(PF-3084014)는 6.2nM의 IC50을 갖는 가역적, 경구 생체 이용 가능, 비경쟁적 및 선택적 γ-세크레타제 억제제입니다. 위장 독성을 최소화하면서 PF-3084014에 의한 Notch 신호 전달 억제는 Notch 수용체 의존성 암 연구를 위한 유망한 접근 방식을 제시합니다.

  • GC30427 structure
    GC30427ELN 318463 racemate
    CAS: 851599-82-1
    Purity: >98%

    ELN 318463 라세미체는 ELN318463의 라세미체입니다.

  • GC30887 structure
    GC30887NGP555
    CAS: 1304630-27-0
    Purity: >98.00%

    NGP555는 γ-분비효소 조절제입니다.

  • GC30954 structure
    GC30954Itanapraced (CHF5074)
    CAS: 749269-83-8
    Purity: >98.00%

    Itanapraced(CHF5074)(CHF5074)는 새로운 γ, Aβ,42 및 A&7#946,7,88946,7,8,8,8,8의 IC50으로 각각 분비를 감소시키는 γ-세크레타제 조절제입니다.

  • GC31012 structure
    GC31012BMS 433796
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    Purity: >98%

    BMS 433796은 알츠하이머병의 형질전환 마우스 모델에서 Aβ 저하 활성을 갖는 γ-분비효소 억제제입니다.