DL-beta-Hydroxybutyryl coenzyme A lithium salt

DL-尾-Hydroxybutyryl coenzyme A lithium is an intermediate in the fermentation of butyric acid and the metabolism of lysine and tryptophan, and is produced from 尾-hydroxybutyric acid by short-chain-CoA synthase.

DL-尾-Hydroxybutyryl coenzyme A lithium (尾-Hydroxybutyryl-CoA) can be produced as an intermediate metabolite via the mitochondrial pathway, where impaired mitochondrial function in cancer cells leads to the accumulation of it. At the same time, DL-尾-Hydroxybutyryl coenzyme A lithium can also be produced via the fatty acid 尾-oxidation, which is accelerated by starvation and fasting, leading to the accumulation of it and thus to diseases caused by certain metabolic adaptations^[1].
DL-尾-Hydroxybutyryl coenzyme A lithium (尾-Hydroxybutyryl-CoA) can act as a cofactor for lysine 尾-hydroxybutyrylation (Kbhb), with elevated levels of histone Kbhb in a streptozotocin (STZ)-induced type 1 diabetes mellitus (T1DM) mouse model^[2].

[1]. Kevin B Koronowski, et al. Ketogenesis impact on liver metabolism revealed by proteomics of lysine 尾-hydroxybutyrylation. Cell Rep. 2021 Aug 3;36(5):109487. 

[2]. Zhongyu Xie, et al. Metabolic Regulation of Gene Expression by Histone Lysine 尾-Hydroxybutyrylation. Mol Cell. 2016 Apr 21;62(2):194-206.