GRK2 degrader-1 (compound 1) is a potent and orally active GRK2 degrader. GRK2 degrader-1 degrades GRK2 via the ubiquitin-proteasome pathway. GRK2 degrader-1 inhibits right ventricular remodeling and elevation of pulmonary artery pressure in a pulmonary artery hypertension (PAH) mouse model. GRK2 degrader-1 can be used for PAH research [1].
References:
[1]. Zuling XU, et al. G protein-coupled receptor kinase 2 (grk2) degradation compounds and use thereof. WO2024165075. 2024-08-15
References:
[1]. Zuling XU, et al. G protein-coupled receptor kinase 2 (grk2) degradation compounds and use thereof. WO2024165075. 2024-08-15