IA-Alkyne |
| Catalog No.GC50641 |
IA-Alkyne(Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide)은 TRP 채널(TRPC) 작용제이며 호흡기 감염 연구의 가능성이 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 930800-38-7
Sample solution is provided at 25 µL, 10mM.
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Broad spectrum cysteine reactive probe. Covalently binds cysteine residues in proteins. Can be utilized for covalent fragment-based ligand discovery (FBLD) and to identify Zn2+-binding cysteines. Used as a click-chemistry handle to attach a fluorophore or biotin to reactive cysteines in proteins for visualization by in-gel fluorescence or identification by mass spectrometry, respectively. Covalently binds cysteine residues in and activates TRPA1 channels.
Backus et al (2016) Proteome-wide covalent ligand discovery in native biological systems. Nature 534 570 PMID:27309814 |Pace and Weerapana et al (2014) A competitive chemical-proteomic platform to identify zinc-binding cysteines. ACS Chem.Biol. 9 258 PMID:24111988 |Macpherson et al (2007) Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445 541 PMID:17237762
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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