Prostaglandins

Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology.

Prostaglandin K2 (PGK2) is the 9,11-diketone formed by the oxidation of PGE2 or PGD2.

15(S)-15-methyl Prostaglandin E1 (15(S)-15-methyl PGE1) is a metabolically stable synthetic analog of PGE1 .

Prostaglandin E1 (PGE1) is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid.

16,16-dimethyl PGF2α is a metabolically stable analog of PGF2α.

16,16-dimethyl PGE1 is a metabolically stable synthetic analog of PGE1.

13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity.

16-phenoxy tetranor PGA2 is a minor metabolite found in human plasma after intravenous administration of sulprostone.

Found in human seminal plasma, 19(R)-hydroxy prostaglandin A2 (19(R)-hydroxy PGA2) is presumed to be a non-enzymatic dehydration metabolite of 19(R)-hydroxy PGE2, which is also found in semen.

3-methoxy PGF1α is a novel analog of PGF1α with a methoxy group in the 3-position of the upper side chain.

16,16-dimethyl PGF2β is a metabolically stable analog of PGF2β.

CAY10580은 강력하고 선택적인 프로스타글란딘 EP4 수용체 작용제입니다(Ki=35nM).

19(R)-hydroxy PGE1 is the major prostaglandin found in the semen of primates, including man.

6-keto PGE1 is a metabolite isolated after the incubation of PGI2 with rabbit liver microsomes.

Prostaglandin E1 (PGE1) is not a major naturally occurring prostaglandin, but it is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction and in neonatal cardiology.

Tolmetin β-D-glucuronide is a major phase II metabolite of tolmetin .

Prostaglandin A1 (PGA1) ethyl ester is a prodrug form of PGA1 with enhanced lipid solubility.

CAY10526은 특정 마이크로솜 PGE2 신타제-1(mPGES1) 억제제입니다. CAY10526은 mPGES1 발현의 선택적 조절을 통해 PGE2 생산을 억제하지만 COX-2에는 영향을 미치지 않는다. CAY10526은 흑색종 이종이식편에서 종양 성장을 유의하게 억제하고 세포자멸사를 증가시킵니다. CAY10526은 BCL-2 및 BCL-XL(항-세포자멸사) 단백질 수준을 감소시키고 BAX 및 BAK(프로-세포자멸사) 및 절단된 카스파제 3 수준을 증가시킵니다. CAY10526은 mPGES1을 발현하는 3개의 흑색종 세포주에서 세포 생존력(IC50<5μM)을 억제합니다.

PGF1β is the C-9 epimer of PGF1α.

A stable analog of PGF 2α 2glyceryl ester

Prostaglandin D1(PGD1) alcohol is the synthetic analog of PGD1 with a primary alcohol in place of the C-1 carboxyl.

AF3485 is a selective 3-aminocarbazole inhibitor of mPGES-1, blocking the synthesis of PGE2 but not PGF2α in A549 cells stimulated with IL-1β (IC50s = 2.9 and >100 µM, respectively).

The actions of many clinical prostaglandins, including those used for estrous synchronization and for reduction of intraocular pressure, are mediated through the FP receptor.

Prostaglandin F2α alcohol (PGF2α-OH) is an analog of PGF2α in which the C-1 carboxyl group has been reduced to a primary alcohol.