Prostaglandins

Misoprostol is a widely sold analog of prostaglandin E1 (PGE1) which has potent but relatively non-selective agonist activity with respect to the prostanoid EP receptor subgroup.

15(R)-15-methyl Prostaglandin F2α methyl ester (15(R)-15-methyl PGF2α methyl ester) is a lipid soluble prodrug form of 15(R)-15-methyl PGF2α with increased membrane permeability.

1a,1b-dihomo Prostaglandin F2α (1a,1b-dihomo PGF2α) is the theoretical product of adrenic acid in the COX pathway.

20-ethyl Prostaglandin F2α (20-ethyl PGF2α) is an analog of PGF2α in which the ω-chain has been extended by the addition of two more methylene carbon atoms.

Carbaprostacyclin is a structural analog of prostacyclin (PGI2) with about 1/10 the receptor binding affinity of prostacyclin.

17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α with potent FP receptor agonist activity and well known intraocular pressure-reducing effects.

17-phenyl trinor-13,14-dihydro Prostaglandin A2 is a synthetic PG analog whose biological activity has not been widely reported.

(±)-Ketoprofen glucuronide is a phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) ketoprofen.

11-deoxy PGF1α is a synthetic analog of PGF1α.

11-deoxy PGF1β is a synthetic analog of PGF1β.

11β-Prostaglandin F2α ethanolamide (11β-PGF2α-EA) is the theoretical hepatic metabolite of PGD2-EA, produced during COX-2 metabolism of the endogenous cannabinoid AEA which is found in brain, liver, and other mammalian tissues.

It has been reported that anandamide (AEA) can be used directly by cyclooxygenase-2 and specific prostaglandin H2 (PGH2) isomerases to produce ethanolamide congeners of the classical PGs, including PGF2α.

Prostaglandin F2α ethanolamide (PGF2α-EA) is produced by cyclooxygenase 2 (COX-2) metabolism of the endogenous cannabinoid, arachidonoyl ethanolamide, found in brain, liver, and other mammalian tissues.

11β-프로스타글란딘 E2(11β-디노프로스톤), 프로스타노이드 유도체는 53.3nM의 Ki로 쥐의 시상하부 막에 대한 [3H]PGE2 결합을 억제합니다.

13,14-dihydro-15-keto Prostaglandin D2 (13,14-dihydro-15-keto PGD2) is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway.

13,14-dihydro-15-keto Prostaglandin E2 (13,14-dihydro-15-keto PGE2) is the primary metabolite of PGE2 in plasma.

13,14-dihydro-15-keto Prostaglandin E2 (13,14-dihydro-15-keto PGE2) is the primary metabolite of PGE2 in plasma.

Many of the effects of prostaglandin D2 (PGD2) are transduced via a traditional 7-transmembrane GPCR, the DP1 receptor.

15(R)-Prostaglandin E2 (15(R)-PGE2) is the C-15 epimer of the naturally occurring 15(S)-PGE2.

15-keto Prostaglandin F2α (15-keto PGF2α) is the first metabolite of PGF2α.

15-keto Prostaglandin F2α (15-keto PGF2α) is the first metabolite of PGF2α.

17-trans PGF3α is a double bond isomer of PGF3α and a potential metabolite of trans dietary fatty acids.

5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1.

PGF3α is a COX product of EPA.