Milbemectin (Synonyms: Milbemycin A3 (~30%) and Milbemycin A4 (~70%) Mixture) |
Catalog No.GC47676
One-Click Copy Product Info
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An insecticidal antibiotic
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1799297-76-9
Sample solution is provided at 25 µL, 10mM.
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Milbemectin is an insecticide used primarily to control mites.1 Milbemectin is a mixture of milbemycin A3 and milbemycin A4 that has acaricidal and nematocidal activity against adult spider mites, spider mite eggs, and C. elegans with IC50 values of 5.3, 41.1, and 9.5 µg/ml, respectively.2 It acts as an allosteric agonist of the Drosophila RDL GABA receptor.3 It is also effective against the pinewood nematode, B. xylophilus with an LC20 of 0.0781 mg/liter.4
1.Macrocyclic InsecticidesMetabolic Pathways of Agrochemicals, Part 2: Insecticides and Fungicides (Metabolic Pathways)95-98(1999) 2.Yang, L.Y., Wang, J.D., Zhang, J., et al.New nemadectin congeners with acaricidal and nematocidal activity from Streptomyces microflavus neau3 Y-3Bioorg. Med. Chem. Lett.23(20)5710-5713(2013) 3.Nakao, T., Banba, S., and Hirase, K.Comparison between the modes of action of novel meta-diamide and macrocyclic lactone insecticides on the RDL GABA receptor.Pestic. Biochem. Physiol.120101-108(2015) 4.Bi, Z., Gong, Y., Huang, X., et al.Efficacy of four nematicides against the reproduction and development of pinewood nematode, Bursaphelenchus xylophilus.J. Nematol.47(2)126-132(2015)
| Cas No. | 1799297-76-9 | SDF | |
| Synonyms | Milbemycin A3 (~30%) and Milbemycin A4 (~70%) Mixture | ||
| Canonical SMILES | C/C(C[C@@H](C)/C=C/C=C(CO1)/[C@@]([C@@]1([H])[C@H](O)C(C)=C2)(O)[C@]2([H])C3=O)=C\C[C@]4([H])C[C@@](O3)([H])C[C@@]5(O[C@]([H])(C)[C@@H](C)CC5)O4.C/C(C[C@@H](C)/C=C/C=C(CO6)/[C@@]([C@@]6([H])[C@H](O)C(C)=C7)(O)[C@]7([H])C8=O)=C\C[C@]9([H])C[C@@](O8)([H])C[C@@]%10(O[C@]([H])(CC)[C@@H](C)CC%10)O9 | ||
| Formula | C31H44O7 (A3) and C32H46O7 (A4) | M.Wt | 0 |
| Solubility | DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)