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ML-210 (Synonyms: DPI10)

Catalog No.GC18705

ML-210은 30nM의 EC50을 갖는 선택적 공유 글루타티온 퍼옥시다제 4(GPX4) 억제제입니다. ML-210은 GPX4 셀레노시스테인 잔기에 결합합니다. ML-210은 항암 활성이 있습니다.

Products are for research use only. Not for human use. We do not sell to patients.

ML-210 Chemical Structure

Cas No.: 1360705-96-9

Size 가격 재고 수량
10mM (in 1mL DMSO)
US$66.00
재고 있음
1mg
US$29.00
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5mg
US$63.00
재고 있음
10mg
US$112.00
재고 있음
50mg
US$336.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Product Documents

Quality Control & SDS

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Background

ML-210 is an inhibitor of glutathione peroxidase 4 (GPX4).[1] It reduces viability of mesenchymal-state KP4 cells, an effect that can be blocked by the arachidonic acid lipoxygenase inhibitors PD 146176 and zileuton. It is also selectively lethal to mutant RAS oncogene-expressing cells (IC50s = 71 and 272 nM in HRASG12V-expressing and wild-type RAS-expressing BJeH cells, respectively).[2]

Reference:
[1]. Viswanathan, V.S., Ryan, M.J., Dhruv, H.D., et al. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature 547(7664), 453-457 (2017).
[2]. Weïwer, M., Bittker, J.A., Lewis, T.A., et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg. Med. Chem. Lett. 22(4), 1822-1826 (2012).

Chemical Properties

Cas No. 1360705-96-9 SDF
Synonyms DPI10
Chemical Name [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-methanone
Canonical SMILES ClC1=CC=C(C(C2=CC=C(Cl)C=C2)N3CCN(C(C4=NOC(C)=C4[N+]([O-])=O)=O)CC3)C=C1
Formula C22H20Cl2N4O4 M.Wt 475.3
Solubility 25mg/mL in DMSO (Need ultrasonic), 10mg/mL in DMF, slightly soluble in ethanol Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.1039 mL 10.5197 mL 21.0393 mL
5 mM 0.4208 mL 2.1039 mL 4.2079 mL
10 mM 0.2104 mL 1.052 mL 2.1039 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 4 reference(s) in Google Scholar.)

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