Noratropine is a major metabolite of Atropine. Noratropine can be formed from Atropine via oxidative N-demethylation and can also be isolated from Anthocercis littorea. Atropine is a competitive muscarinic acetylcholine receptor ( mAChR ) antagonist. Atropine can be used in research on anti-myopia and bradycardia [1] [2] [3] [4].
References:
[1]. Evans WC, et al. Distribution of alkaloids in Anthocercis littorea and A. viscosa. Phytochemistry. 1973;12(10):2505-2507.
[2]. Chen HX, et al. LC-MS for identification and elucidation of the structure of in-vivo and in-vitro metabolites of atropine. Chromatographia. 2007;65:413-418.
[3]. NADOR K, et al. N-Allyl-noratropine. J Med Pharm Chem. 1961 Jan 10;3:183-5.
[4]. Wang Z, et al. Indirect competitive enzyme-linked immunosorbent assay based on a broad-spectrum monoclonal antibody for tropane alkaloids detection in pig urine, pork and cereal flours. Food chemistry. 2021 Feb 01;337:127617.
References:
[1]. Evans WC, et al. Distribution of alkaloids in Anthocercis littorea and A. viscosa. Phytochemistry. 1973;12(10):2505-2507.
[2]. Chen HX, et al. LC-MS for identification and elucidation of the structure of in-vivo and in-vitro metabolites of atropine. Chromatographia. 2007;65:413-418.
[3]. NADOR K, et al. N-Allyl-noratropine. J Med Pharm Chem. 1961 Jan 10;3:183-5.
[4]. Wang Z, et al. Indirect competitive enzyme-linked immunosorbent assay based on a broad-spectrum monoclonal antibody for tropane alkaloids detection in pig urine, pork and cereal flours. Food chemistry. 2021 Feb 01;337:127617.