Pilsicainide (hydrochloride) (Synonyms: SUN 1165) |
Catalog No.GC49193
One-Click Copy Product Info
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필시카이니드(염산염)(SUN-1165)는 경구 활성 나트륨 채널 차단제이자 강력한 클래스 Ic 항부정맥제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 88069-49-2
Sample solution is provided at 25 µL, 10mM.
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Pilsicainide is a class Ic antiarrhythmic agent.1,2 It shortens action potential duration in canine Purkinje fibers, as well as increases the ratio of the effective refractory period to the duration of action potential in guinea pig atrial muscle strips, when used at a concentration of 10 µg/ml.1 Pilsicainide (3-10 mg/kg) restores sinus rhythm in a canine model of ventricular multifocal arrhythmias.2 It also suppresses arrhythmias induced by ouabain or halothane and epinephrine in dogs. Formulations containing pilsicainide have been used in the treatment of supraventricular and ventricular tachycardia.
1.Hattori, Y., Inomata, N., Aisaka, K., et al.Electrophysiological actions of N-(2,6-dimethylphenyl)-8-pyrrolizidine-acetamide hydrochloride hemihydrate (SUN 1165), a new antiarrhythmic agentJ. Cardiovasc. Pharmacol.8(5)998-1002(1986) 2.Aisaka, K., Hidaka, T., Inomata, N., et al.N-(2,6-Dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate (SUN 1165): A new potent and long-acting antiarrhythmic agentArzneimittelforschung35(8)1239-1245(1985)
| Cas No. | 88069-49-2 | SDF | |
| Synonyms | SUN 1165 | ||
| Canonical SMILES | O=C(CC12N(CCC2)CCC1)NC3=C(C)C=CC=C3C.Cl | ||
| Formula | C17H24N2O·HCl | M.Wt | 308.9 |
| Solubility | DMF: 20 mg/ml,DMSO: 25 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 10 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.2373 mL | 16.1865 mL | 32.3729 mL |
| 5 mM | 647.5 μL | 3.2373 mL | 6.4746 mL |
| 10 mM | 323.7 μL | 1.6186 mL | 3.2373 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A crystalline solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)