Polysarcosine100 is an amine-functionalized hydrophilic polymer.1,2,3 Surface modification of liposomes with polysarcosine polymers between 10 and 100 units long have been used to increase circulation half-life.2,3
References:
[1]. Weber, B., Birke, A., Fischer, K., et al.Solution properties of polysarcosine: From absolute and relative molar mass determinations to complement activationMacromolecules51(7)2653–2661(2018).
[2]. Weber, B., Seidl, C., Schwiertz, D., et al.Polysarcosine-based lipids: From lipopolypeptoid micelles to stealth-like lipids in Langmuir Blodgett monolayersPolymers (Basel)8(12)427(2016).
[3]. Bleher, S., Buck, J., Muhl, C., et al.Poly(sarcosine) surface modification imparts stealth-like properties to liposomesSmall15(50)e1904716(2019).