Reactive Oxygen Species
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Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.
ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Products Related to Reactive Oxygen Species(505)
- GC47436HT-2 Toxin-13C22CAS: 1486469-92-4Purity: >98.00%
An internal standard for the quantification of HT-2 toxin
- GC47439Hydralazine-d4 (hydrochloride)CAS: 2749234-32-8Purity: >99.00%
A neuropeptide with diverse biological activities
- GC47549L-Carnosine-d4CAS: 2714339-90-7Purity: >99.00%
A neuropeptide with diverse biological activities
- GC47659Methyl 3,4-DihydroxyphenylacetateCAS: 25379-88-8Purity: >98.00%
A polyphenol with antioxidant and antiviral activities
- GC47826Omeprazole sulfone-d3CAS: 2749628-17-7Purity: >99.00%
A neuropeptide with diverse biological activities
- GC47932Pelargonidin 3-O-glucoside (chloride)CAS: 18466-51-8Purity: >95.00%
칼리스테핀(Pelargonidin 3-O-glucoside) 염화물은 딸기와 초크베리에서 발견할 수 있는 안토시아닌입니다.
- GC47977PropiconazoleCAS: 60207-90-1Purity: >96.00%
Propiconazole은 구강 투여 활성 N-치환 트리아졸 Propiconazole로 항진균 활성을 가지고 있다.
- GC47978Propiconazole-d3 (nitrate)CAS: 2699607-26-4Purity: >99.00%
A neuropeptide with diverse biological activities
- GC47979Propiconazole-d7CAS: 1246818-14-3Purity: >99.00%
An internal standard for the quantification of propiconazole
- GC47980Propionyl-L-carnitine-d3 (chloride)CAS: 1334532-19-2Purity: >99.00%
An internal standard for the quantification of propionyl-L-carnitine
- GC48019Quercetin (hydrate)CAS: 849061-97-8Purity: >96.00%
Quercetin (hydrate) is the dihydrate form of the flavonoid quercetin, which possesses various biological activities.
- GC48120T-2 Toxin-13C24CAS: 21259-20-1Purity: >98.00%
A neuropeptide with diverse biological activities
- GC48162Theobromine-d6CAS: 117490-40-1Purity: >99.00%
An internal standard for the quantification of theobromine
- GC48194trans-Resveratrol-d4CAS: 1089051-56-8Purity: >99.00%
An internal standard for the quantification of trans-resveratrol
- GC48247Verrucarin ACAS: 3148-09-2Purity: ≥70.00%
Verrucarin A(Muconomycin A)는 병원균 곰팡이 Myrothecium verrucaria에서 파생된 Type D 거대고리 진균독으로 단백질 합성의 억제제입니다. Verrucarin A는 백혈병 세포주의 성장을 억제하고 대식세포에서 카스파제와 세포자멸사 및 염증 신호를 활성화합니다. Verrucarin A는 p38 MAPK의 인산화를 효과적으로 증가시켰고 ERK/Akt의 인산화를 감소시켰다. Verrucarin A는 p21과 p53의 유도를 통해 세포주기 조절을 완화했습니다.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC47436 | HT-2 Toxin-13C22 | 1486469-92-4 | >98.00% | |
An internal standard for the quantification of HT-2 toxin | ||||
| GC47439 | Hydralazine-d4 (hydrochloride) | 2749234-32-8 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47477 | JKE-1674 | 2421119-60-8 | >98.00% | |
JKE-1674는 경구 활성 글루타티온 퍼옥시다제 4(GPX4) 억제제이자 GPX4 억제제 ML-210의 활성 대사 산물입니다. JKE-1674, 니트로이속사졸 고리가 α-니트로케톡심으로 대체된 ML-210의 유사체. JKE-1674는 니트릴 산화물 JKE-1777로 변환할 수 있습니다. JKE-1674는 ML-210과 동일한 방식으로 LOX-IMVI 세포를 죽이고 ferroptosis 억제제에 의해 완전히 구제됩니다. | ||||
| GC47478 | JKE-1716 | 2421118-05-8 | >98.00% | |
JKE-1716은 강력하고 선택적인 니트로산 함유 GPX4 억제제입니다. | ||||
| GC47549 | L-Carnosine-d4 | 2714339-90-7 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47582 | Lupulone | 468-28-0 | >95.00% | |
Lupulone은 홉 식물 H.의 베타산입니다. | ||||
| GC47659 | Methyl 3,4-Dihydroxyphenylacetate | 25379-88-8 | >98.00% | |
A polyphenol with antioxidant and antiviral activities | ||||
| GC47683 | MitoB-d15 | - | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47684 | MitoP-d15 | - | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47826 | Omeprazole sulfone-d3 | 2749628-17-7 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47932 | Pelargonidin 3-O-glucoside (chloride) | 18466-51-8 | >95.00% | |
칼리스테핀(Pelargonidin 3-O-glucoside) 염화물은 딸기와 초크베리에서 발견할 수 있는 안토시아닌입니다. | ||||
| GC47955 | Phloroglucinol | 108-73-6 | >99.00% | |
A phenol with diverse biological activities | ||||
| GC47977 | Propiconazole | 60207-90-1 | >96.00% | |
Propiconazole은 구강 투여 활성 N-치환 트리아졸 Propiconazole로 항진균 활성을 가지고 있다. | ||||
| GC47978 | Propiconazole-d3 (nitrate) | 2699607-26-4 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47979 | Propiconazole-d7 | 1246818-14-3 | >99.00% | |
An internal standard for the quantification of propiconazole | ||||
| GC47980 | Propionyl-L-carnitine-d3 (chloride) | 1334532-19-2 | >99.00% | |
An internal standard for the quantification of propionyl-L-carnitine | ||||
| GC48019 | Quercetin (hydrate) | 849061-97-8 | >96.00% | |
Quercetin (hydrate) is the dihydrate form of the flavonoid quercetin, which possesses various biological activities. | ||||
| GC48020 | Quercetin-d3 (hydrate) | - | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC48029 | RC363 | 2584411-86-7 | >98.00% | |
An inhibitor of ferroptosis | ||||
| GC48030 | RC574 | 2584411-87-8 | >98.00% | |
An inhibitor of ferroptosis | ||||
| GC48120 | T-2 Toxin-13C24 | 21259-20-1 | >98.00% | |
A neuropeptide with diverse biological activities | ||||
| GC48162 | Theobromine-d6 | 117490-40-1 | >99.00% | |
An internal standard for the quantification of theobromine | ||||
| GC48194 | trans-Resveratrol-d4 | 1089051-56-8 | >99.00% | |
An internal standard for the quantification of trans-resveratrol | ||||
| GC48247 | Verrucarin A | 3148-09-2 | ≥70.00% | |
Verrucarin A(Muconomycin A)는 병원균 곰팡이 Myrothecium verrucaria에서 파생된 Type D 거대고리 진균독으로 단백질 합성의 억제제입니다. Verrucarin A는 백혈병 세포주의 성장을 억제하고 대식세포에서 카스파제와 세포자멸사 및 염증 신호를 활성화합니다. Verrucarin A는 p38 MAPK의 인산화를 효과적으로 증가시켰고 ERK/Akt의 인산화를 감소시켰다. Verrucarin A는 p21과 p53의 유도를 통해 세포주기 조절을 완화했습니다. | ||||