GLPBio

E3 Ligase Ligand-Linker Conjugate

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E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc.MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

Products Related to E3 Ligase Ligand-Linker Conjugate(201)

  • GC70024 structure
    GC70024Thalidomide-O-C6-azide
    CAS: 2411389-65-4
    Purity: >99.00%

    Thalidomide-O-C6-azide는 E3 연결 효소 리간드-링커 결합체(E3 Ligase Ligand-Linker Conjugates)의 일종으로, cereblon 리간드를 기반으로 한 Thalidomide와 1개의 링커(linker)가 포함되어 있습니다.

  • GC70816 structure
    GC70816Pomalidomide-C5-azide
    CAS: 2434629-02-2
    Purity: >97.00%

    Pomalidomide-C5-azide 은 E3 범소 연결효소-뇌 백단백질(CRBN) 배합체-연결자 접합물이다.

  • GC73001 structure
    GC73001Thalidomide-4-O-C10-NH2 hydrochloride
    Purity: >95.00%

    Thalidomide-4-O-C10-NH2 hydrochloride는 CRBN 단백질의 채용에 사용되는 탈리도마이드 기반의 세레블론 리간드이다.

  • GC73071 structure
    GC73071Thalidomide-5-PEG3-NH2 hydrochloride
    CAS: 2761385-81-1
    Purity: >97.00%

    Thalidomide-5-PEG3-NH2 hydrochloride은 탈리도마이드 기반 세레블론 리간드와 PROTAC 기술에 사용되는 링커를 통합한 합성된 E3리간드 리간드 링커 공액이다.

  • GC73095 structure
    GC73095(S,S,R)-AHPC-C6-NH2 hydrochloride
    Purity: >97.00%

    (S,S,R)-AHPC-C6-NH2 hydrochloride는 S,S,R-AHPC-C6-NH2의 염화 염화 염 형태이다.

  • GC73164 structure
    GC73164Pomalidomide-C6-O-C5-O-C4-COOH
    CAS: 2375774-54-0
    Purity: >98.00%

    Pomalidomide-C6-O-C5-O-C4-COOH는 Pomalidomide 기반의 cereblon 리간드와 링커로 이루어진 E3 ligase 리간드 링커 공액이다.

  • GC73431 structure
    GC73431Pomalidomide-C11-NH2 hydrochloride
    CAS: 2722611-55-2

    Pomalidomide-C11-NH2 hydrochloride은 CRBN 단백질을 모집하는 데 사용되는 파마도민 기반 cereblon(CRBN) 배합체다.

  • GC73558 structure
    GC73558Pomalidomide-5-C9-NH2 hydrochloride
    CAS: 2925306-22-3
    Purity: >98.00%

    Pomalidomide-5-C9-NH2 hydrochloride은 CRBN 단백질을 모집하는 데 사용되는 파마도민 기반 cereblon(CRBN) 배합체다.

  • GC73559 structure
    GC73559Pomalidomide-5-C11-NH2 hydrochloride
    Purity: >98.00%

    Pomalidomide-5-C11-NH2 hydrochloride는 CRBN 단백질의 채용에 사용되는 Pomalidomide-based cereblon (CRBN) 리간드이다.

  • GC73560 structure
    GC73560Pomalidomide-5-C12-NH2 hydrochloride
    Purity: >98.00%

    Pomalidomide-5-C12-NH2 hydrochloride는 CRBN 단백질의 채용에 사용되는 Pomalidomide-based cereblon (CRBN) 리간드이다.

  • GC73862 structure
    GC73862Lenalidomide-C5-acid
    CAS: 2338824-30-7
    Purity: >96.00%

    Lenalidomide-C5-acid 는 CRBN 단백질 모집에 사용되는 레나타민 기반 E3 연결 효소 배합체-조인트 우연물입니다.

  • GC74706 structure
    GC74706Thalidomide-5-O-CH2-COOH
    CAS: 2467425-53-0
    Purity: >95.00%

    Thalidomide-5-O-CH2-COOH는 탈리도마이드와 NH-PEG3-NH-Boc로 이루어진 E3리가제 리간드 링커 공액이다.

  • GC80883 structure
    GC80883Thalidomide-O-amide-C5-NH2 hydrochloride
    CAS: 2716130-28-6
    Purity: >95.50%

    Thalidomide-O-amide-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology [1] [2] .

  • GC80897 structure
    GC80897Desamino lenalidomide-C2-COOH
    CAS: 2703770-71-0
    Purity: >98.00%

    Desamino lenalidomide-C2-COOH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80898 structure
    GC80898Thalidomide-O-C2-alkyne
    CAS: 2357110-34-8
    Purity: >99.50%

    Thalidomide-O-C2-alkyne is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80899 structure
    GC80899Thalidomide-azetidine-C-OH
    CAS: 2241314-93-0
    Purity: >98.50%

    Thalidomide-azetidine-C-OH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80900 structure
    GC80900(S)-Glutarimide-amide-Py-piperidine-CHO
    CAS: 2649400-06-4
    Purity: >99.00%

    (S)-Glutarimide-amide-Py-piperidine-CHO is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80901 structure
    GC80901Desamino lenalidomide-piperidine-CO
    CAS: 2413037-88-2
    Purity: >98.00%

    Desamino lenalidomide-piperidine-CO is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80902 structure
    GC80902Desamino lenalidomide-Pip hydrochloride
    CAS: 2291360-60-4
    Purity: >99.00%

    Desamino lenalidomide-Pip hydrochloride is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80903 structure
    GC80903Pomalidomide-piperazine hydrochloride
    CAS: 2230956-83-7
    Purity: >97.00%

    Pomalidomide-piperazine hydrochloride is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80904 structure
    GC80904Thalidomide-piperidin-4-ylmethanol
    CAS: 2229717-49-9
    Purity: >99.00%

    Thalidomide-piperidin-4-ylmethanol is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80905 structure
    GC80905Thalidomide-6-F-5-pip-CHO
    CAS: 2505502-00-9
    Purity: >95.00%

    Thalidomide-6-F-5-pip-CHO is a synthetic E3 ligase ligand-conjugate that can be used for the synthesis of PROTACs, such as DN1679 [1] .

  • GC80906 structure
    GC80906Thalidomide 5-fluoride 6-piperidine-C-OH
    CAS: 2505501-99-3
    Purity: >98.00%

    Thalidomide 5-fluoride 6-piperidine-C-OH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80907 structure
    GC80907Desamino lenalidomide-acetylene-C2-NH2 TFA
    CAS: 3065251-37-5
    Purity: >98.00%

    Desamino lenalidomide-acetylene-C2-NH2 TFA is an E3 ligand-linker conjugate that incorporates a ligand based on CRBN and a linker, and can be used for the synthesis of PROTAC.