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HCV Protease

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Hepatitis C virus (HCV) protease is an enzyme, either viral or cellular, that catalyzes the hydrolysis of the long polyprotein precursor (approximately 3000 amino acids) encoded by HCV genome into at least ten individual proteins, including four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A and NS5B). The commonly studied HCV proteases are two virally encode proteases involved in the viral replication of HCV, including HCV NS2/3 protease, a highly hydrophobic protease responsible for the cleavage of NS2 and NS3, and HCV NS3-4A serine protease, a covalent heterodimer responsible for cleavage at four sites of the HCV polyprotein.

Products Related to HCV Protease(37)

  • GC25117 structure
    GC25117Azvudine
    CAS: 1011529-10-4
    Purity: >98%

    Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).

  • GC32305 structure
    GC32305ACH-806 (GS9132)
    CAS: 870142-71-5
    Purity: >98%

    ACH-806(GS9132)은 14nM의 EC50으로 C형 간염 바이러스(HCV) 복제를 억제할 수 있는 NS4A 길항제입니다.

  • GC37921 structure
    GC37921Voxilaprevir
    CAS: 1535212-07-7
    Purity: >99.50%

    복실라프레비르(GS-9857)는 범유전자형 항바이러스 활성을 갖는 HCV NS3/4A 프로테아제 억제제(PI)의 비공유 가역적 억제제입니다.

  • GC60947 structure
    GC60947Isoeuphorbetin
    CAS: 50886-61-8
    Purity: >98%

    Viola philippica에서 분리된 이량체 쿠마린인 Isoeuphorbetin은 IC50이 3.63 μg/mL인 강력한 HCV 프로테아제 억제제입니다.

  • GC64016 structure
    GC64016Samatasvir
    CAS: 1312547-19-5
    Purity: >99.00%

    Samatasvir(IDX71)는 HCV 복제의 강력한 경구 활성 NS5A 억제제입니다.

  • GC64038 structure
    GC64038Simeprevir-13C,d3
    CAS: 923604-59-5
    Purity: >98%

    Simeprevir-13C,d3(TMC435-13C,d3)은 Simeprevir로 표시된 13C 및 중수소입니다.

  • GC64065 structure
    GC64065Coblopasvir
    CAS: 1312608-46-0
    Purity: >98%

    Coblopasvir(KW-136)는 범유전자형 비구조 단백질 5A(NS5A) 억제제입니다.

  • GC64066 structure
    GC64066Coblopasvir dihydrochloride
    CAS: 1966138-53-3
    Purity: >98%

    Coblopasvir(KW-136) dihydrochloride는 범유전자형 비구조 단백질 5A(NS5A) 억제제입니다.

  • GC65345 structure
    GC65345BI 653048
    CAS: 1198784-72-3
    Purity: >98%

    BI 653048은 55nM의 IC50 값을 갖는 선택적 경구 활성 비스테로이드성 글루코코르티코이드(GC) 작용제입니다.

  • GC68453 structure
    GC68453ITMN 4077
    CAS: 790305-05-4
    Purity: >99.00%
  • GC71538 structure
    GC71538IDX184
    CAS: 1036915-08-8
    Purity: >99.00%

    IDX184는 HCV 복제의 강력하고 구강 생물학적 이용 가능한 억제제입니다.

  • GC71540 structure
    GC71540JTK-109
    CAS: 480462-62-2

    JTK-109은 C형간염 바이러스 NS5B RNA 의존성 RNA 중합효소의 강력한 억제제다.

  • GP10026 structure
    GP10026Hepatitis C virus
    Purity: >98%

    Hepatitis C virus, (C48H88N10O13S), a peptide with the sequence H2N-Leu-Leu-Ala-Leu-Leu-Ser-Cys-Leu-Thr-Val-OH, MW= 1045.34.