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HIV Protease

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Human immunodeficiency virus (HIV) protease, belonging to the aspartic proteinase family, is an enzyme encoded by the pol open reading frame (ORF) of HIV genome that catalyze the posttranslational processing of the HIV polyproteins to yield structural proteins of the viral core and enzymes. The chemical structure of a HIV protease molecule is a symmetrical homodimer in which the interface is formed primarily by a four-stranded antiparallel β-sheet. A conserved D25-T26-G27 triad has been identified in each HIV protease monomer, which is positioned in a loop forming part of the catalytic site. HIV protease has been found to cleave peptide bonds in the p55 gag and p160 gag-pol polyproteins as well as in various cellular proteins in vitro, including calmodulin, pro-interleukin 1β and NF-KB.

Products Related to HIV Protease(35)

  • GC36872 structure
    GC36872Pepstatin Trifluoroacetate
    Purity: >99.00%

    Pepstatin Trifluoroacetate(Pepstatin A Trifluoroacetate)는 방선균에 의해 생산되는 특정 아스파르트산 프로테아제 억제제이며, IC50은 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM 및 260 nM입니다. 각각 카제인-프로타아제, 카제인-산 프로테아제 및 헤모글로빈-산 프로테아제.

  • GC39068 structure
    GC39068Rosamultin
    CAS: 88515-58-6
    Purity: >98.00%

    Rosamultin은 Potentilla anserinaL에서 분리된 19α-hydroxyursane-type triterpenoid입니다.

  • GC43358 structure
    GC43358Cytochalasin A
    CAS: 14110-64-6
    Purity: >98.00%

    시토칼라신 A는 시토칼라신 B의 산화된 유도체인 세포 투과성 곰팡이 독소입니다.

  • GC64331 structure
    GC64331Ritonavir-13C,d3
    CAS: 155213-67-5
    Purity: >98%
  • GC65440 structure
    GC65440ddCTP trisodium
    Purity: >99.00%

    ddCTP trisodium은 2',3'-dideoxyribonucleoside 5'-triphosphates(ddNTP) 중 하나로서 DNA 시퀀싱을 위한 DNA 중합효소의 사슬 연장 억제제 역할을 합니다.

  • GC65584 structure
    GC65584TMC310911
    CAS: 1000287-05-7
    Purity: >99.00%

    TMC310911은 야생형 HIV-1에 대해 2.2nM에서 14.2nM 범위의 EC50 값을 갖는 강력하고 경구 활성인 HIV 1형(HIV-1) 프로테아제 억제제입니다.

  • GC66400 structure
    GC66400Hinokinin
    CAS: 26543-89-5
    Purity: >99.00%

    히노키닌(화합물 1)은 Hypoestes aristate의 줄기에서 분리된 화합물입니다. 821d96072c2d58d8970e76f526b0f6b8히노키닌은 HIV-1 프로테아제 효소의 중등도 활성을 나타냅니다.821d96072c2d58d8970e76f526b0f6b8

  • GC71023 structure
    GC71023CL-197
    CAS: 1030595-07-3
    Purity: >99.00%

    CL-197 는 경구용 활성 장효 퓨린 항 HIV 뉴클레오티드 역전록 효소 억제제(NRTI)의 일종이다.

  • GC71947 structure
    GC71947Acetyl-binankadsurin A
    CAS: 77174-33-5

    Acetyl-binankadsurin A (화합물 5) 은 긴 발 남쪽 오미자에서 분리 된 메티노이드입니다.

  • GC81868 structure
    GC81868Acetyl-pepstatin ammonium
    Purity: >98.00%

    Acetyl-pepstatin ammonium is an aspartic protease ( PRs ) inhibitor that targets HIV-1 protease and XMRV protease with K i values of 13 nM and 712 nM, respectively.

  • GN10545 structure
    GN10545Escin IA
    CAS: 123748-68-5
    Purity: >98.00%