GLPBio

Hedgehog

Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.

Products Related to Hedgehog(43)

  • GC39359 structure
    GC39359Ciliobrevin D
    CAS: 1370554-01-0
    Purity: >98.00%

    Ciliobrevin D는 dynein ATPase 활성을 억제하는 억제제로 모터 단백질의 사이클링 활동을 방지한다.

  • GC43346 structure
    GC43346Cyclopamine-KAAD
    CAS: 306387-90-6
    Purity: >96.00%

    고슴도치 신호 억제제인 Cyclopamine-KAAD는 부드러운 길항제입니다.

  • GC43809 structure
    GC43809Hedgehog Antagonist VIII
    CAS: 330796-24-2
    Purity: >98.00%

    Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened.

  • GC44321 structure
    GC44321Nat-20(S)-yne
    CAS: 1397692-46-4
    Purity: >90.00%

    Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors.

  • GC44458 structure
    GC44458N-Palmitoyl-L-Aspartate
    CAS: 1782-17-8
    Purity: >98.00%

    N-Palmitoyl-L-aspartate is a natural N-acylaspartate that inhibits Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog.

  • GC44855 structure
    GC44855RU-SKI 43 (hydrochloride)
    CAS: 1782573-67-4
    Purity: >98.50%

    RU-SKI 43(염산염)은 IC50이 850nM인 강력하고 선택적인 고슴도치 아실트랜스퍼라제(Hhat) 억제제입니다. RU-SKI 43(염산염)은 Smoothened-independent non-canonical signaling을 통해 Gli-1 활성화를 감소시키고 Akt 및 mTOR 경로 활성을 감소시킵니다. RU-SKI 43(염산염)은 항암 활성이 있습니다.

  • GC45090 structure
    GC45090Triparanol
    CAS: 78-41-1
    Purity: >98.00%

    Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 μM), which is an enzyme involved in the biosynthesis of cholesterol.

  • GC47435 structure
    GC47435HPI-1 (hydrate)
    Purity: >95.00%

    A Hedgehog pathway inhibitor

  • GC47474 structure
    GC47474Itraconazole-d5
    CAS: 1217510-38-7
    Purity: >99.00%

    An internal standard for the quantification of itraconazole

  • GC47570 structure
    GC47570Lipoxygenin
    CAS: 2247911-68-6
    Purity: >98.00%

    An inhibitor of 5-LO

  • GC48062 structure
    GC48062RU-SKI 201 (hydrochloride)
    CAS: 2320262-09-5
    Purity: >95.00%

    A neuropeptide with diverse biological activities

  • GC49651 structure
    GC4965119-alkyne Cholesterol
    CAS: 2058319-71-2
    Purity: >95.00%

    클릭 화학을 위한 콜레스테롤의 알카인 유도체

  • GC64134 structure
    GC64134Hh-Ag1.5
    CAS: 612542-14-0
    Purity: >99.00%

    Hh-Ag1.5(SAg1.5)는 EC50이 1nM인 강력한 고슴도치(Hh) 작용제입니다.

  • GC66390 structure
    GC663903-epi-Vitamin D3
    CAS: 57651-82-8
    Purity: >98%

    비타민 D3 유사체인 3-에피-비타민 D3(에피콜레칼시페롤)(화합물 4)는 U87MG 세포에서 측정된 IC50이 39.2 μM인 Hedgehog 경로 억제제입니다.821d96072c2d58d8970e76f526b0f6b8

  • GC72838 structure
    GC728381-Methyladenosine-d3 hydrochloride

    1-Methyladenosine-d3 hydrochloride은 1-메트라데노신으로 표기된 중수소의 염화물 소금 형태이다.

  • GC73310 structure
    GC73310SMO-IN-2
    CAS: 1822355-27-0
    Purity: >98.00%

    SMO-IN-2 (화합물 1)은 hedgehog (Hh) 신호 경로에 대한 IC50 값이 123.4 nM인 강력한 스무드 (SMO) 억제제이다.

  • GC73776 structure
    GC73776DS-1-38
    Purity: >99.00%

    DS-1-38는 소닉 헤지혹 (SHH) 신호를 차단하는 EYA1 적대자.

  • GC74091 structure
    GC74091Itraconazole-d9
    CAS: 1309272-50-1
    Purity: >97.00%

    Itraconazole-d9는 이트라코나졸로 표기된 중수소이다.

  • GC91424 structure
    GC91424S1PL-IN-31
    CAS: 1538574-95-6
    Purity: >98.00%

    S1PL-IN-31는 스핑고신-1-인산 (S1P) 라이아제의 억제제입니다 (IC50 = 210 nM).