Thiamethoxam-d3

Thiamethoxam-d3 is intended for use as an internal standard for the quantification of thiamethoxam by GC- or LC-MS. Thiamethoxam is a neonicotinoid insecticide and a prodrug form of the neonicotinoid insecticide clothianidin .1,2 It binds to nicotinic acetylcholine receptors (nAChRs) with low affinity (IC50 = 5,000 nM for housefly head membranes) and does not activate non-desensitizing nAChRs in cockroach neurons in vitro (IC50 = >3,000 nM).2 Thiamethoxam induces mortality in a variety of insects, including A. craccivora, M. persicae, and S. littoralis when administered in contact/feeding assays (LC80s = 12, 3, and 3 mg AI/L, respectively) and via systemic administration (LC80s = 0.8, 0.2, and 0.8 mg AI/L, respectively), as well as N. lugens and D. balteata in contact/feeding assays (LC80s = 0.8 mg AI/L for both).1 Thiamethoxam also induces 100% mortality of second instar larvae of the fall armyworm S. frugiperda and the tobacco budworm H. virescens in leaf-dip bioassays when used at a concentration of 200 mg/L.2 Formulations containing thiamethoxam have been used in the control of insects in agriculture.