Lagosin is a polyene macrolide antibiotic. Lagosin exerts its antifungal effects by interacting with membrane sterols and possesses broad-spectrum antifungal and antitumor activities. Lagosin can be used in research related to antifungal infections and antitumor studies[1-4].
In vitro, Lagosin (1-2μg/ml) was used to treat Chinese hamster V79 cells for 2 hours, followed by stimulation with [14C]bleomycin A2. Lagosin significantly enhanced the cellular uptake of [14C]bleomycin A2[5]. Lagosin (50μg/ml) was used to treat L-form cells of Escherichia coli W1655F+ for 6 hours. Lagosin inhibited the growth of the L-form cells[6].
In vivo, Lagosin (20mg/kg; single injection) was administered via intraperitoneal injection to Balb/C mice bearing EMT6 solid tumors. Lagosin alone did not exhibit significant cytotoxicity against the tumor cells[6].
References:
[1] Dembitsky VM, Terent'ev AO, Baranin SV, et al. Boron's Double Edge-Antibiotics, Toxins, and the Fine Line Between Them. Molecules. 2026 Mar 18;31(6):1021.
[2] Peng C, An D, Ding WX, et al. Fungichromin production by Streptomyces sp. WP-1, an endophyte from Pinus dabeshanensis, and its antifungal activity against Fusarium oxysporum. Appl Microbiol Biotechnol. 2020 Dec;104(24):10437-10449.
[3] Pandey RC, Guenther EC, Aszalos AA, et al. Physicochemical and biological comparison of polyene macrolide antibiotics fungichromin, lagosin and cogomycin. J Antibiot (Tokyo). 1982 Aug;35(8):988-96.
[4] Arora HR. Effects of polyene antibiotics on the heart. A study with nystatin and lagosin. Med Pharmacol Exp Int J Exp Med. 1965;13(3):155-60.
[5] Akiyama SI, Hidaka K, Komiyama S, et al. Control of permeation of bleomycin A2 by polyene antibiotics in cultured Chinese hamster cells. Cancer Res. 1979 Dec;39(12):5150-4.
[6] Twentyman PR. The effect of bleomycin and pentamycin in combination on the survival of EMT6 mouse tumour cells in vitro and in vivo. Br J Cancer. 1976 Apr;33(4):459-64.