Lck Inhibitor III free base is a Lck inhibitor with an IC50 of 867 nM. Lck Inhibitor III free base inhibits the production of interleukin-2 ( IL-2 ). Lck Inhibitor III free base can be used in the study of autoimmune diseases [1].
In Vitro, Lck Inhibitor III free base (Compound 12h) inhibits purified lymphocyte-specific kinase (Lck) with an IC50 of 867 nM[1]. The intrinsic clearance of Lck Inhibitor III free base (1 μM; 1 h) in cryopreserved rat hepatocyte suspensions is 48 mL/min kg[1]. Lck Inhibitor III free base inhibits IL-2 production in Jurkat cells with an IC50 of 1.270 μM[1].
References:
[1]. Sabat M, et al. The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck). Bioorganic & medicinal chemistry letters. 2006 Dec 01;16(23):5973-7.
In Vitro, Lck Inhibitor III free base (Compound 12h) inhibits purified lymphocyte-specific kinase (Lck) with an IC50 of 867 nM[1]. The intrinsic clearance of Lck Inhibitor III free base (1 μM; 1 h) in cryopreserved rat hepatocyte suspensions is 48 mL/min kg[1]. Lck Inhibitor III free base inhibits IL-2 production in Jurkat cells with an IC50 of 1.270 μM[1].
References:
[1]. Sabat M, et al. The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck). Bioorganic & medicinal chemistry letters. 2006 Dec 01;16(23):5973-7.