LD003 is a lipid prodrug form of the synthetic glucocorticoid dexamethasone that has been used in the formation of lipid nanoparticles (LNPs) for siRNA and mRNA delivery in vivo.[1] LNPs containing LD003 and encapsulating cytosine-guanine-containing oligodeoxynucleotide (CpG) reduce the blood levels of Il-10, chemokine (C-X-C motif) ligand 1 (CXCL1), TNF-α, IL-1β, and IL-6 in mice. LNPs containing LD003 and encapsulating siRNA targeting mouse coagulation Factor VII (FVII) decrease injection site immune infiltration and hepatic levels of FVII in mice.
LD003
Catalog No.: GC91569Purity:>98.00%
LD003 is a lipid prodrug form of the synthetic glucocorticoid dexamethasone that has been used in the formation of lipid nanoparticles (LNPs) for siRNA and mRNA delivery in vivo.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2102449-40-9
5 mgIn Stock
$175.00
1
10 mgIn Stock
$315.00
1
25 mgIn Stock
$568.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 5 mg | $175.00 | In Stock | 1 | |
| 10 mg | $315.00 | In Stock | 1 | |
| 25 mg | $568.00 | In Stock | 1 |
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Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Product Documents
Purity:>98.00%Appearance:A solid
Chemical Properties
CAS No.
2102449-40-9
Molecular Formula
C44H65FO8
Molecular Weight
741
Solubility
Ethanol: Soluble: ≥10 mg/ml
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
Reviews
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