LY3541860 |
Catalog No.GC79343
One-Click Copy Product Info
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LY3541860 is a selective anti- CD19 antibody that both binds human CD19 with high affinity and selectively binds human B cells ( K d values: 76.8 pM and 94.5 nM for humans and cynomolgus monkeys, respectively).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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In Vivo, LY3541860 (0.01-1.0 mg/kg; s.c.; weekly) inhibits B cell activation and immunoglobulin secretion in female humanized NSG mice (with a human IgM secretion attenuation of 57-78%)[1].
In Vitro, LY3541860 (1.6-1000 nM) binds human and cynomolgus CD19 with high affinity (Kd values: 76.8 pM, 94.5 nM, respectively[1]. LY3541860 (30 minutes) selectively binds human B cells in whole blood (EC50 = 0.184 ± 0.008 nM)[1]. LY3541860 (0.001 nM-10 nM; 30 min) inhibits B cell proliferation (IC50 = 0.008 nM)[1]. LY3541860 (0.1 pM-10 nM) can inhibit CpG-induced CD69 expression (IC50 = 0.006 nM)[1].
References:
[1]. Boyles JS, et al. A nondepleting anti-CD19 antibody impairs B cell function and inhibits autoimmune diseases. JCI Insight. 2023;8(13):e166137. Published 2023 Jul 10.
| Cas No. | SDF | ||
| Formula | M.Wt | 144.7 | |
| Solubility | Storage | Store at -20°C | |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.9109 mL | 34.5543 mL | 69.1085 mL |
| 5 mM | 1.3822 mL | 6.9109 mL | 13.8217 mL |
| 10 mM | 691.1 μL | 3.4554 mL | 6.9109 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A liquid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)