Potent P-gp inhibitor with good selectivity towards BCRP pump (EC50 values 0.05 μM, 0.69 μM, 9.3 μM, and 73 μM for Caco-2, MDR1, MRP1, and BCRP inhibition, respectively), with potential as novel anticancer agent with both cytostatic and cytotoxic characteristics. MC70, as an inhibitor of the ABC transporter ABCB1 (aka MDR1), potentiates Doxorubicin efficacy in colon and breast cancer in vitro treatment.
MC70 hydrochloride
Catalog No.: GB40271Purity:>98%
Potent P-gp inhibitor with good selectivity towards BCRP pump (EC50 values 0.05 μM, 0.69 μM, 9.3 μM, and 73 μM for Caco-2, MDR1, MRP1, and BCRP inhibition, respectively), with potential as novel anticancer agent with both cytostatic and cytotoxic characteristics. MC70, as an inhibitor of the ABC transporter ABCB1 (aka MDR1), potentiates Doxorubicin efficacy in colon and breast cancer in vitro treatment.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2108830-71-1
10mgIn Stock
$413.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mg | $413.00 | In Stock | 1 |
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com
Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Chemical Properties
CAS No.
2108830-71-1
Molecular Formula
C24H25NO3.HCl
Molecular Weight
411.92
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
Reviews
Review for MC70 hydrochloride
Rating: 5
- 5 Star100%
- 4 Star0%
- 3 Star0%
- 2 Star0%
- 1 Star0%