MeDZ lipid is a zwitterion-type ionizable endosomal membrane destabilizer and anti-inflammatory agent that promotes endosomal escape. When incorporated into LNP formulations, MeDZ lipid enhances mRNA expression in lymph node antigen-presenting cells and promotes cytotoxic T cell activation. MeDZ lipid is compatible with existing targeted nanoparticle formulations to improve mRNA delivery efficiency [1].
In Vivo, MeDZ (25%) LNPs (5 μg Luc mRNA per mouse; s.c.; single injection) deliver mRNA to mouse lymph nodes with 1.7-fold higher endosomal escape efficiency than BNT162b2 LNPs, resulting in enhanced luciferase expression[1].
References:
[1]. Zhao Y, et al. Low reactogenicity and high tumour antigen expression from mRNA-LNPs with membrane-destabilizing zwitterionic lipids. Nat Biomed Eng. Published online December 18, 2025.
In Vivo, MeDZ (25%) LNPs (5 μg Luc mRNA per mouse; s.c.; single injection) deliver mRNA to mouse lymph nodes with 1.7-fold higher endosomal escape efficiency than BNT162b2 LNPs, resulting in enhanced luciferase expression[1].
References:
[1]. Zhao Y, et al. Low reactogenicity and high tumour antigen expression from mRNA-LNPs with membrane-destabilizing zwitterionic lipids. Nat Biomed Eng. Published online December 18, 2025.