GLPBio

MU1409

Catalog No.: GC83623Purity:>98.50%
COASDSData Sheet
MU1409 is an inhibitor of MRE11 nuclease with an IC50 of 12.1 μM.

Products are for research use only. Not for human use. We do not sell to patients.

MU1409
Cas No.: 2379671-78-8
10mM (in 1mL DMSO)In Stock
$226.00
1
5mgIn Stock
$225.00
1
10mgIn Stock
$360.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Description

MU1409 is an inhibitor of MRE11 nuclease with an IC50 of 12.1 μM. Additionally, MU1409 also inhibits FEN1 and EXO1, with IC50 values of 24.2 and 176.4 μM, respectively. MU1409 affects DNA repair in cells, preventing the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for research on BRCA2 mutation-induced cancers [1].

References:
[1]. Nikulenkov F, et al. Discovery of new inhibitors of nuclease MRE11. Eur J Med Chem. 2025 Mar 5;285:117226.

Product Documents

Purity:>98.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2379671-78-8
Molecular Formula
C20H14BrN3O3S
Molecular Weight
456.31
Solubility
DMSO: 10 mg/mL (21.91 mM; ultrasonic and warming and heat to 60°C)
Storage
Store at -20°C
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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