N,N'-Dimetldrazine (1,2-Dimetldrazine) didrochloride is a tumor inducer that induces colon tumors in rodents.
N,N'-Dimetldrazine (DMH) (20 mg/kg; sc; once weekly, 24 wk) can induce colon cancer in ICR mice[1].N,N'-Dimetldrazine (20 mg/kg ; sc; 20 wk) induces intraperitoneal intestinal tumors in rats, an effect that is potently inhibited by Lactobacillus acidophilus. Mice that consumed a beef diet that mimicked a "Western" diet had a higher incidence of colon cancer than grain-fed mice (83% vs. 31%, respectively)[2].
References:
[1]. Nakamura S, et al. Morphogenesis of colonic adenomas in mice treated with N,N'-dimetldrazine didrochloride. Acta Pathol Jpn. 1982 May;32(3):473-81.
[2]. Goldin BR, et al. Effect of Lactobacillus acidophilus dietary supplements on 1,2-dimetldrazine didrochloride-induced intestinal cancer in rats. J Natl Cancer Inst. 1980 Feb;64(2):263-5.