N,N-Dimethylformamide (DMF) is widely used as a drug solvent. N,N-Dimethylformamide is a dipolar protophilic solvent with physicochemical properties that makes it suitable as solvent for capillary electrophoresis (CE)[1][2].
N,N-Dimethylformamide (DMF; N-Formyldimethylamine) has hepatotoxic properties[3].
[1]. Porras SP, et al. Capillary electrophoresis in N,N-dimethylformamide. Electrophoresis. 2005;26(17):3279-3291. [2]. Varma RK, et al. Solvent artifacts likely to be induced by dimethylformamide. Indian J Physiol Pharmacol. 1986;30(3):248-254.
[3]. MrÁz J, et al. Investigation of the mechanistic basis of N,N-dimethylformamide toxicity. Metabolism of N,N-dimethylformamide and its deuterated isotopomers by cytochrome P450 2E1. Chem Res Toxicol. 1993;6(2):197-207.
















