GLPBio

NITD-688

Catalog No.: GC70799Purity:99.00%
COASDSData Sheet
NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein.

Products are for research use only. Not for human use. We do not sell to patients.

NITD-688
Cas No.: 2407227-31-8
10mM (in 1mL DMSO)In Stock
$2,231.00
1
1 mgIn Stock
$405.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Description

NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV).

NITD-688 shows antiviral activity against all four serotypes of dengue virus (DENV), with EC50 values of 8 to 38 nM[1].
NITD-688 shows antiviral activity against DENV-2 infected PBMCs, with an EC50 value of 0.94 nM[1].
NITD-688 directly binds to wild-type but not mutant NS4B protein[1].

NITD-688 (30 mg/kg, oral gavage, twice daily for 3 days) demonstrates excellent antiviral efficacy in infected AG129 mice[1].
NITD-688 (15-300 mg/kg, oral gavage, per day for 7 days) is well tolerated in rats and dogs (toxicology studies)[1].

References:
[1]. Moquin SA, et al. NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models. Sci Transl Med. 2021 Feb 3;13(579):eabb2181.

Product Documents

Purity:99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2407227-31-8
Molecular Formula
C25H32N4O3S2
Molecular Weight
500.68
Solubility
DMSO : 100 mg/mL (199.73 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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