GLPBio

Phox-I2

Catalog No.: GC70477Purity:>99.00%
COASDSData Sheet
Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM.

Products are for research use only. Not for human use. We do not sell to patients.

Phox-I2
Cas No.: 353495-22-4
1 mgIn Stock
$60.00
1
5 mgIn Stock
$158.00
1
10 mgIn Stock
$227.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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Description

Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production.

Phox-I2 is effective in inhibiting NOX2-mediated superoxide production dose-dependently in dHL-60 cells and primary human neutrophils without detectable toxicity[1].

References:
[1]. Emily E Bosco, et al. Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation. Chem Biol. 2012 Feb 24;19(2):228-42.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
353495-22-4
Molecular Formula
C18H15N3O4
Molecular Weight
337.33
Solubility
DMSO : 250 mg/mL (741.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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