GLPBio

PL1

Catalog No.: GC91578Purity:>95.00%
COASDSData Sheet
PL1 is a multi-tail ionizable cationic phospholipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA.

Products are for research use only. Not for human use. We do not sell to patients.

PL1
Cas No.: 2274812-94-9
500 µgIn Stock
$111.00
1
1 mgIn Stock
$176.00
1
5 mgIn Stock
$830.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Description

PL1 is a multi-tail ionizable cationic phospholipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA.1 LNPs containing PL1 and encapsulating mRNA encoding the co-stimulatory receptor CD137 or OX40 increase T cell antitumor immunity in various mouse xenograft models.

References:
[1].Li, W., Zhang, X., Zhang, C., et al.Biomimetic nanoparticles deliver mRNAs encoding costimulatory receptors and enhance T cell mediated cancer immunotherapyNat. Commun.12(1)7264(2021).

Product Documents

Purity:>95.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2274812-94-9
Molecular Formula
C61H121N2O10P
Molecular Weight
1073.6
Solubility
Chloroform: Soluble,Methanol: Slightly soluble
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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