GLPBio

PLX-3618

Catalog No.: GC27962Purity:>99.50%
COASDSData Sheet

PLX-3618 is a selective BRD4 molecular glue degrader with a DC50 of 12.2 nM. 

Products are for research use only. Not for human use. We do not sell to patients.

PLX-3618
Cas No.: 2851986-76-8
10mM (in 1mL DMSO)In Stock
$410.00
1
1mgIn Stock
$122.00
1
5mgIn Stock
$310.00
1
10mgIn Stock
$504.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Description

PLX-3618 is a selective BRD4 molecular glue degrader with a DC50 of 12.2 nM. PLX-3618 promotes the polyubiquitination and subsequent proteasomal degradation of BRD4 by recruiting the E3 ligase substrate receptor DCAF11. PLX-3618 inhibits the proliferation of various cancer cells and induces apoptosis in acute myeloid leukemia (AML) cells. PLX-3618 can be used in studies related to acute myeloid leukemia (AML)[1].

References:

[1]. Parker GS, et al. Discovery of Monovalent Direct Degraders of BRD4 that Act via the Recruitment of DCAF11. Mol Cancer Ther. 2024;23(10):1446-1458.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2851986-76-8
Molecular Formula
C32H27N9O2S
Molecular Weight
601.68
Solubility
DMSO : 100 mg/mL (166.20 mM; Need ultrasonic)
Storage
Store at -20°C
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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