PSB-KD107 |
Catalog No.GC48004
One-Click Copy Product Info
|
A GPR18 agonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 955121-65-0
Sample solution is provided at 25 µL, 10mM.
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PSB-KD107 is an agonist of the orphan G protein-coupled receptor GPR18 (EC50 = 0.56 µM in a β-arrestin recruitment assay using CHO cells expressing the human receptor).1,2 It is selective for GPR18 over GPR55, as well as cannabinoid (CB) receptor 1 (CB1) and CB2, at 10 µM but also binds to the adenosine A2A receptor (Ki = 0.33 µM for the rat receptor).1,3
1.Schoeder, C.T., Kaleta, M., Mahardhika, A.B., et al.Structure-activity relationships of imidazothiazinones and analogs as antagonists of the cannabinoid-activated orphan G protein-coupled receptor GPR18Eur. J. Med. Chem.155381-397(2018) 2.Schoeder, C.T., Mahardhika, A.B., Drabczyńska, A., et al.Discovery of tricyclic xanthines as agonists of the cannabinoid-activated orphan G?protein-coupled receptor GPR18ACS Med. Chem. Lett.(2020) 3.Drabczyńska, A., MÜller, C.E., Schiedel, A., et al.Phenylethyl-substituted pyrimido[2,1-f]purinediones and related compounds: Structure-activity relationships as adenosine A1 and A2A receptor ligandsBioorg. Med. Chem.15(22)6956-6974(2007)
| Cas No. | 955121-65-0 | SDF | |
| Canonical SMILES | O=C1C2=C(N(C)C(N1C)=O)N=C3N2CCCN3CCC4=CNC5=C4C=CC=C5 | ||
| Formula | C20H22N6O2 | M.Wt | 378.4 |
| Solubility | DMF: 2 mg/ml,DMSO: 2 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.6427 mL | 13.2135 mL | 26.4271 mL |
| 5 mM | 528.5 μL | 2.6427 mL | 5.2854 mL |
| 10 mM | 264.3 μL | 1.3214 mL | 2.6427 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)