GLPBio

PSMA I&T

Catalog No.: GC73198Purity:>99.00%
COASDSData Sheet
PSMA I&T is an effective inhibitor of prostate-specific membrane antigen (PSMA).

Products are for research use only. Not for human use. We do not sell to patients.

PSMA I&T
Cas No.: 2192281-54-0
1 mgIn Stock
$342.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Description

PSMA I&T is an effective inhibitor of prostate-specific membrane antigen (PSMA). PSMA I&T can be used for SPECT/CT imaging and radionuclide studies in triple-negative breast cancer and prostate cancer (PCa).

PSMA I&T has high specificity for PSMA-expressing PCa cells, xenografted PCa, and in vitro kidneys, with equilibrium binding constants Kd of 3.9 nM and 5.6 nM for LNCaP and LS174T-PSMA, respectively[1].

PSMA I&T (0.1-1 nM, intravenous injection, single dose) shows specific accumulation in mouse xenografts, kidneys, spleens, lungs, salivary glands, and adrenal glands[1].

References:
[1]. Chatalic KL, et al. Towards Personalized Treatment of Prostate Cancer: PSMA I&T, a Promising Prostate-Specific Membrane Antigen-Targeted Theranostic Agent. Theranostics. 2016 Apr 12;6(6):849-61.
[2]. Amelie Heesch, et al. The prostate-specific membrane antigen holds potential as a vascular target for endogenous radiotherapy with [177Lu]Lu-PSMA-I&T for triple-negative breast cancer. Breast Cancer Res. 2024 Feb 20;26(1):30.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2192281-54-0
Molecular Formula
C63H92IN11O23
Molecular Weight
1498.37
Solubility
DMSO : 100 mg/mL (66.74 mM; ultrasonic and warming and heat to 60°C); H2O : < 0.1 mg/mL (insoluble)
Storage
-20°C, sealed storage, away from moisture
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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