GLPBio

Radulone A

Catalog No.: GC92256Purity:>70.00%
COASDSData Sheet
Radulone A is a sesquiterpene fungal metabolite originally isolated from R. confluens that has diverse biological activities.

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Radulone A
Cas No.: 221374-79-4
1mgIn Stock
$245.00
1
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Citations

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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Description

Radulone A is a sesquiterpene fungal metabolite originally isolated from R. confluens that has diverse biological activities. It is active against eight bacterial strains (MICs = 41-406 µM). Radulone A inhibits ADP-, collagen-, arachidonic acid-, or phorbol 12-myristate 13-acetate-induced aggregation of isolated human platelets (IC50 = 2, 28, 53, and 38 µM, respectively). It induces cytotoxicity in L1210 skin lymphocytic leukemia, HL-60 promyeoloblast leukemia, and HeLa cervical cancer cells and COS-7 kidney fibroblasts (IC50s = 1, 2, 20, and 16 µM).

Product Documents

Purity:>70.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
221374-79-4
Chemical Name
(3S,8aS,8bS,9S)-2,3,8,8a-tetrahydro-9-hydroxy-3,6,8a-trimethyl-3,8b-methano-8bH-cyclobuta[5,6]benzo[1,2-b]pyran-5(7H)-one
SMILES
CC(C1=O)=C2CC[C@]2(C)[C@@]34OC[C@](C)(C=C14)[C@@H]3O
Molecular Formula
C15H18O3
Molecular Weight
246.30162
Solubility
Dichloromethane: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
Storage
-20°C
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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