Aryl Hydrocarbon Receptor
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Aryl Hydrocarbon Receptor (AhR or AHR or ahr or ahR) is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic (aryl) hydrocarbons, and regulates xenobiotic-metabolizing enzymes such as cytochrome P450s, most notably cyp 1A1.
Aryl Hydrocarbon Receptor is a member of the family of basic helix-loop-helix transcription factors. AhR binds several exogenous ligands including natural plant flavonoids, polyphenolics and indoles, as well as synthetic polycyclic aromatic hydrocarbons and dioxin-like compounds. AhR is a cytosolic transcription factor that is normally inactive, binding to several co-chaperones. Upon ligand binding to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the chaperones dissociate resulting in AhR translocating into the nucleus and dimerizing with ARNT (AhR nuclear translocator), leading to changes in gene transcription.
Products Related to Aryl Hydrocarbon Receptor(40)
- GC64208AHR antagonist 5 free baseCAS: 2247950-42-9Purity: >98%
AHR antagonist 5 free base is a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor. AHR antagonist 5 free base effectively blocks AHR from translocating from the cytoplasm to the nucleus. AHR antagonist 5 free base is highly selective for AHR over other receptors, transporters, and kinases.
- GC64275AHR antagonist 5CAS: 2247953-39-3Purity: >98%
AHR antagonist 5, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018195397, example 39, has an IC50 of < 0.5 ?Μ. AHR antagonist 5 significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1.
- GC68631AhR agonist 2Purity: >99.50%
AhR agonist 2 (Compound 12a) is an effective aryl hydrocarbon receptor (AhR) agonist with an EC50 of 0.03 nM. AhR agonist 2 induces rapid nuclear enrichment of AhR, triggers downstream gene transcription, and promotes skin barrier repair. AhR agonist 2 has the potential to be studied for psoriasis treatment.
- GC69908Skatole-d3CAS: 111399-60-1Purity: >98.00%
Skatole-d3 is the deuterated form of Skatole. Skatole is a substance produced by intestinal bacteria that activates aryl hydrocarbon receptors and regulates intestinal epithelial cell function through p38 activation.
- GC70236L-Kynurenine-13C10 sulfate hemihydratePurity: >99.00%
L-Kynurenine-13C10 (sulfate hemihydrate) is the 13C labeled L-Kynurenine sulfate.
- GC72948Dibenzo(a,i)pyreneCAS: 189-55-9Purity: >98.00%
Dibenzo(a,i)pyrene is a 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) receptor ligand.
- GC7416425-Hydroxytachysterol3CAS: 39932-44-0Purity: >98.00%
25-droxytacsterol3 is the metabolite of Vitamin D3.
- GC79341N-MethylscatoleCAS: 875-30-9Purity: >98.00%
N-Methylscatole (compound 70130) is a weak aryl hydrocarbon receptor ( AhR ) agonist exhibiting no significant antagonistic activity [1] .
- GC793429,10-DichlorophenanthreneCAS: 17219-94-2Purity: >98%
9,10-Dichlorophenanthrene is a chlorinated polycyclic aromatic hydrocarbon and is generally regarded as a carcinogen.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC64208 | AHR antagonist 5 free base | 2247950-42-9 | >98% | |
AHR antagonist 5 free base is a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor. AHR antagonist 5 free base effectively blocks AHR from translocating from the cytoplasm to the nucleus. AHR antagonist 5 free base is highly selective for AHR over other receptors, transporters, and kinases. | ||||
| GC64275 | AHR antagonist 5 | 2247953-39-3 | >98% | |
AHR antagonist 5, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018195397, example 39, has an IC50 of < 0.5 ?Μ. AHR antagonist 5 significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1. | ||||
| GC64898 | L-Kynurenine-d4-1 | 194546-33-3 | >98% | |
| GC67892 | CHD-5 | 289494-16-2 | >98% | |
| GC68631 | AhR agonist 2 | - | >99.50% | |
AhR agonist 2 (Compound 12a) is an effective aryl hydrocarbon receptor (AhR) agonist with an EC50 of 0.03 nM. AhR agonist 2 induces rapid nuclear enrichment of AhR, triggers downstream gene transcription, and promotes skin barrier repair. AhR agonist 2 has the potential to be studied for psoriasis treatment. | ||||
| GC69347 | KYN-101 | 2247950-73-6 | >98.00% | |
KYN-101 is an effective, selective, and orally active AHR inhibitor. KYN-101 reduces CYP1A1 mRNA expression. KYN-101 has anti-cancer activity. | ||||
| GC69908 | Skatole-d3 | 111399-60-1 | >98.00% | |
Skatole-d3 is the deuterated form of Skatole. Skatole is a substance produced by intestinal bacteria that activates aryl hydrocarbon receptors and regulates intestinal epithelial cell function through p38 activation. | ||||
| GC70236 | L-Kynurenine-13C10 sulfate hemihydrate | - | >99.00% | |
L-Kynurenine-13C10 (sulfate hemihydrate) is the 13C labeled L-Kynurenine sulfate. | ||||
| GC72826 | CB7993113 | 819827-50-4 | >98.00% | |
CB7993113 is a potent AHR antagonist, with an IC50 of 0.33 μM. | ||||
| GC72948 | Dibenzo(a,i)pyrene | 189-55-9 | >98.00% | |
Dibenzo(a,i)pyrene is a 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) receptor ligand. | ||||
| GC74164 | 25-Hydroxytachysterol3 | 39932-44-0 | >98.00% | |
25-droxytacsterol3 is the metabolite of Vitamin D3. | ||||
| GC79337 | ZSTK3744 | - | >98.00% | |
ZSTK3744 is an aryl hydrocarbon receptor ( AhR ) agonist. | ||||
| GC79341 | N-Methylscatole | 875-30-9 | >98.00% | |
N-Methylscatole (compound 70130) is a weak aryl hydrocarbon receptor ( AhR ) agonist exhibiting no significant antagonistic activity [1] . | ||||
| GC79342 | 9,10-Dichlorophenanthrene | 17219-94-2 | >98% | |
9,10-Dichlorophenanthrene is a chlorinated polycyclic aromatic hydrocarbon and is generally regarded as a carcinogen. | ||||
| GC79393 | PY109 | 2378039-23-5 | >99.00% | |
PY109 is an orally active and highly selective aryl hydrocarbon receptor ( AHR ) agonist. | ||||
| GN10706 | Diosimin | 520-27-4 | >98.00% | |