Royleanonic acid is an abietan-type diterpene found in the leaves of Salvia officinalis L. Royleanonic acid is a porcine pancreatic lipase inhibitor with an IC50 of 35 μg/mL [1].
In Vivo, Royleanonic acid (200 mg/kg; p.o.; single dose) does not inhibit olive oil-induced serum triglyceride elevation in male ddY mice[1].
In Vitro, Royleanonic acid (1-300 μg/mL; 30 min) inhibits porcine pancreatic lipase activity with an IC50 of 35 μg/mL[1].
References:
[1]. Ninomiya K, et al. Carnosic acid, a new class of lipid absorption inhibitor from sage. Bioorg Med Chem Lett. 2004;14(8):1943-1946.
In Vivo, Royleanonic acid (200 mg/kg; p.o.; single dose) does not inhibit olive oil-induced serum triglyceride elevation in male ddY mice[1].
In Vitro, Royleanonic acid (1-300 μg/mL; 30 min) inhibits porcine pancreatic lipase activity with an IC50 of 35 μg/mL[1].
References:
[1]. Ninomiya K, et al. Carnosic acid, a new class of lipid absorption inhibitor from sage. Bioorg Med Chem Lett. 2004;14(8):1943-1946.