Acetylleucine -d 10 (N-Acetyl-DL-leucine-d 10 ) is the deuterium labeled Acetylleucine. Acetylleucine (N-Acetyl-DL-leucine), orally active compound, can be used for the research of acute vestibular vertigo, cerebellar ataxia and nystagmus [1] [2].
In Vitro, Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
References:
[1]. Feil K, et, al. Update on the Pharmacotherapy of Cerebellar Ataxia and Nystagmus. Cerebellum. 2016 Feb;15(1):38-42.
[2]. Clément G, et, al. Effects of vestibular training on motion sickness, nystagmus, and subjective vertical. J Vestib Res. 2007;17(5-6):227-37.
[3]. Günther L, et al. N-acetyl-L-leucine accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus. PLoS One. 2015 Mar 24;10(3):e0120891.
In Vitro, Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
References:
[1]. Feil K, et, al. Update on the Pharmacotherapy of Cerebellar Ataxia and Nystagmus. Cerebellum. 2016 Feb;15(1):38-42.
[2]. Clément G, et, al. Effects of vestibular training on motion sickness, nystagmus, and subjective vertical. J Vestib Res. 2007;17(5-6):227-37.
[3]. Günther L, et al. N-acetyl-L-leucine accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus. PLoS One. 2015 Mar 24;10(3):e0120891.