Antimalarial agent 58 is a diaminoquinoline methanol compound with weak in vitro activity against Plasmodium falciparum strain D6, and no activity against Plasmodium falciparum strains W2, C235 and C2A [1].
In Vitro, Antimalarial agent 58 (Compound 308384) exhibits weak in vitro activity against Pf D6 with an IC90 of 380 ng/mL and no measurable activity (IC90 > 500 ng/mL) against Pf W2, Pf C235, and Pf C2A strains of Plasmodium falciparum[1].
References:
[1]. Milner E, et al. Structure-activity relationships of 4-position diamine quinoline methanols as intermittent preventative treatment (IPT) against Plasmodium falciparum. J Med Chem. 2011;54(18):6277-6285.
In Vitro, Antimalarial agent 58 (Compound 308384) exhibits weak in vitro activity against Pf D6 with an IC90 of 380 ng/mL and no measurable activity (IC90 > 500 ng/mL) against Pf W2, Pf C235, and Pf C2A strains of Plasmodium falciparum[1].
References:
[1]. Milner E, et al. Structure-activity relationships of 4-position diamine quinoline methanols as intermittent preventative treatment (IPT) against Plasmodium falciparum. J Med Chem. 2011;54(18):6277-6285.