Adenosine-5'-O-(1-Thiotriphosphate)(ATP(αS))is an ATP analog, which is obtained by mixing ATP Rp and Sp isomers in a 1:1 ratio. ATP(αS) is a potent agonist of β-cell adenylyl cyclase, P2Y11 receptor, and rP2Y1 receptor[1]. ATP(αS) was identified as a P2Y2 and P2Y6 receptor-specific ligand that acts as a neurotransmitter in the central nervous system (CNS) [2].
References:
[1]. Biochem. A chimeric rat brain P2Y1 receptor tagged with GFP: high-affinity ligand recognition of adenosine diphosphates and triphosphates and selectivity identical to that of wild-type receptor. Vohringer et al. (2000). Pharmacol. 59 (7):791.
[2]. R SchÄfer,G Reiser. ATPalphaS is a ligand for P2Y receptors in synaptosomal membranes: solubilization of [35S]ATPalphaS binding proteins associated with G-proteins.1999 Apr;34(4):303-17. doi: 10.1016/s0197-0186(99)00014-5.