GLPBio

Bcl-xL

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BCL-XL (B-cell lymphoma-extra large), an anti-apoptotic member of the BCL-2 family proteins, is prominently found in the inner membrane of mitochondria and characterized by containing all four BCL-2 homology (BH) domains (BH1 to BH4). A hydrophobic cleft (the BH3-binding groove) formed by apposition of the BH1, BH2 and BH3 domains has been identified in the molecular surface of BCL-XL, through which it interacts with pro-apoptotic BCL-2 proteins, Bax and Bak, to inhibit apoptosis. Moreover, BCL-XL also exhibits anti-autophagy abilities to avoid autophagic cell death by binding to protein Beclin 1, which is required to initiate the formation of autophagasome in autophagy.

Products Related to Bcl-xL(8)

  • GC13317 structure
    GC13317WEHI-539 hydrochloride
    CAS: 2070018-33-4
    Purity: >98.00%

    El clorhidrato de WEHI-539 es un inhibidor selectivo de Bcl-XL con una IC50 de 1,1 nM.

  • GC11510 structure
    GC11510HA14-1
    CAS: 65673-63-4
    Purity: >98.00%

    A Bcl-2 inhibitor

  • GC11921 structure
    GC11921WEHI-539
    CAS: 1431866-33-9
    Purity: >98%

    A selective Bcl-xL inhibitor

  • GC12139 structure
    GC12139Gambogic Acid
    CAS: 2752-65-0
    Purity: >98%

    Gambogic Acid Un activador de caspasas permeable a las células e inductor de la apoptosis, comúnmente utilizado en estudios sobre cáncer de mama, pulmón e hígado.

  • GC12649 structure
    GC12649TW-37
    CAS: 877877-35-5
    Purity: >99.00%

    An inhibitor of the Bcl-2 family proteins

  • GC17234 structure
    GC17234ABT-737
    CAS: 852808-04-9
    Purity: >98.00%

    ABT-737, como analogo de BH3, es un inhibidor de la familia Bcl-2 que suprime la actividad de Bcl-2, Bcl-xL y Bcl-w, con un valor IC 50 <1nM

  • GC17512 structure
    GC17512A-1155463
    CAS: 1235034-55-5
    Purity: >99.50%

    A-1155463 es un inhibidor de BCL-XL altamente potente y selectivo con un EC50 de 70 nM en c&eacute;lulas Molt-4.

  • GC17513 structure
    GC17513A-1331852
    CAS: 1430844-80-6
    Purity: >98.00%

    A-1331852 es un inhibidor selectivo de BCL-XL disponible por v&Iacute;a oral con una Ki de menos de 10 pM.