Bis-PEG2000-COOH is a dicarboxyl-terminated polyethylene glycol and surface modification reagent with hydrophilic, biocompatible properties. Bis-PEG2000-COOH coats superparamagnetic iron oxide nanoparticles to prepare carriers for conjugating antigen p210 and adjuvant CpG oligodeoxynucleotides in nanovaccine formulation [1] [2] [3].
In Vitro, Bis-PEG2000-COOH (60 mg; 12 h) successfully modifies Fe3O4@OA nanoparticles to form Fe3O4@DA-PEG[1]. Bis-PEG2000-COOH (100 mg; 24 h) successfully grafts to amino-functionalized SED-150 long afterglow nanospheres[2].
References:
[1]. Fernandes S, et al. Magnetic Nanoparticle-Based Hyperthermia Mediates Drug Delivery and Impairs the Tumorigenic Capacity of Quiescent Colorectal Cancer Stem Cells. ACS Appl Mater Interfaces. 2021 Apr 14;13(14):15959-15972.
[2]. Li ZJ, et al. A facile and effective method to prepare long-persistent phosphorescent nanospheres and its potential application for in vivo imaging. J. Master. Chem. 2012 Oct 4;22:24713.
[3]. Zhang L, et al. A nanovaccine for immune activation and prophylactic protection of atherosclerosis in mouse models. Nat Commun. 2025;16(1):2111. Published 2025 Mar 2.
In Vitro, Bis-PEG2000-COOH (60 mg; 12 h) successfully modifies Fe3O4@OA nanoparticles to form Fe3O4@DA-PEG[1]. Bis-PEG2000-COOH (100 mg; 24 h) successfully grafts to amino-functionalized SED-150 long afterglow nanospheres[2].
References:
[1]. Fernandes S, et al. Magnetic Nanoparticle-Based Hyperthermia Mediates Drug Delivery and Impairs the Tumorigenic Capacity of Quiescent Colorectal Cancer Stem Cells. ACS Appl Mater Interfaces. 2021 Apr 14;13(14):15959-15972.
[2]. Li ZJ, et al. A facile and effective method to prepare long-persistent phosphorescent nanospheres and its potential application for in vivo imaging. J. Master. Chem. 2012 Oct 4;22:24713.
[3]. Zhang L, et al. A nanovaccine for immune activation and prophylactic protection of atherosclerosis in mouse models. Nat Commun. 2025;16(1):2111. Published 2025 Mar 2.