GLPBio

BTR2000 TFA

Catalog No.: GC81019Purity:>98.50%
COASDSData Sheet
BTR2000 TFA, a specifically KLHL20 ligand, is capable of binding to the KLHL20 Kelch domain with high affinity.

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BTR2000 TFA
5mgIn Stock
$153.00
1
10mgIn Stock
$245.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citas (Citations)

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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    387(6734) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Descripción (Description)

BTR2000 TFA, a specifically KLHL20 ligand, is capable of binding to the KLHL20 Kelch domain with high affinity. BTR2000 TFA can be used as a ligand for E3 ligase for the synthesis of BTR2004 [1] [2].

References:
[1]. Farrell BM, et, al. A synthetic KLHL20 ligand to validate CUL3KLHL20 as a potent E3 ligase for targeted protein degradation. Genes Dev. 2022 Sep 1;36(17-18):1031-1042.
[2]. Fechtmeyer PH, et, al. Temporal and Spatial Characterization of CUL3KLHL20-driven Targeted Degradation of BET family, BRD Proteins by the Macrocycle-based Degrader BTR2004. bioRxiv. 2024 Dec 7:2024.12.07.627262.

Documentos del producto (Product Documents)

Purity:>98.50%Appearance:A solid
COASDSData Sheet

Propiedades químicas (Chemical Properties)

Fórmula molecular
C31H43F3N6O9S2
Peso molecular
764.83
Solubilidad
DMSO: 62.5 mg/mL (81.72 mM; Need ultrasonic)
Almacenamiento
Store at -20°C
Condiciones de envío
Las muestras de evaluación se envían con acumuladores de frío. Los demás tamaños se envían a temperatura ambiente o, previa solicitud, con acumuladores de frío.

Calculadoras (Calculators)Molaridad / Dilución / Peso molecular / Conversión de unidades / Formulación in vivo / Solubilidad

g/mol

Reviews

Review for BTR2000 TFA

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