GLPBio

CD73

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CD73 (Ecto-5′-nucleotidase), a component of the purinergic signaling pathway, is a 70-kD glycosylphosphatidylinositol-anchored cell surface protein encoded by the NT5E gene.

CD73 has both enzymatic and non-enzymatic functions in cells. As a nucleotidase, CD73 catalyzes the hydrolysis of AMP into adenosine and phosphate, and CD73-generated adenosine plays an important role in tumor immunoescape. CD73 plays a crucial role in switching on adenosinergic signaling. CD73 also functions as a signal and adhesive molecule that can regulate cell interaction with extracellular matrix components, such as laminin and fibronectin, to mediate the invasive and metastatic properties of cancers. Both the enzymatic and non-enzymatic functions of CD73 are involved in cancer-associated processes and are not completely independent of each other.

Overexpression of CD73 is associated with resistance to antitumor agents. Knockdown of CD73 inhibits in vitro cell growth, cell cycle progression and cell migration in many cancers. CD73 and its associated pathways may be useful as therapeutic targets.

Products Related to CD73(15)

  • GC31914 structure
    GC31914CD73-IN-1
    CAS: 2132396-40-6
    Purity: >98.50%

    CD73-IN-1 es un inhibidor de CD73 que se puede utilizar en el tratamiento del cÁncer extraÍdo de la patente WO 2017153952 A1, ejemplo 80.

  • GC32795 structure
    GC32795PSB-12379
    CAS: 1802226-78-3
    Purity: >99.50%

    PSB-12379, un anÁlogo de nucleÓtido, es un potente inhibidor de ecto-5'-nucleotidasa (CD73) con Kis de 9,03 nM (rata) y 2,21 nM (humano).

  • GC36587 structure
    GC36587MethADP
    CAS: 3768-14-7
    Purity: >99.50%

    MethADP es un inhibidor especÍfico de CD73.

  • GC36588 structure
    GC36588MethADP sodium salt
    CAS: 89016-30-8
    Purity: >98%

    MetADP (sal de sodio) es un inhibidor especÍfico de CD73.

  • GC62331 structure
    GC62331CD73-IN-3
    CAS: 2375815-63-5
    Purity: >99.50%

    CD73-IN-3 es un potente inhibidor de CD73 (IC50 = 7,3 nM en el ensayo de células humanas Calu6). CD73-IN-3, ejemplo 2 extraÍdo de la patente WO2019168744 A1, tiene potencial para la investigaciÓn del cÁncer.

  • GC62452 structure
    GC62452CD73-IN-4
    CAS: 2216764-29-1
    Purity: >99.50%

    CD73-IN-4 es un inhibidor potente y selectivo del Ácido metilenfosfÓnico CD73, con una IC50 de 2,6 nM para CD73 humano.

  • GC62694 structure
    GC62694OP-5244
    CAS: 2381268-71-7
    Purity: >99.50%

    OP-5244 es un inhibidor potente y activo por vÍa oral de CD73, con una IC50 de 0,25 nM.

  • GC62695 structure
    GC62695OP-5244 sodium
    Purity: >98%

    El sodio OP-5244 es un inhibidor potente y activo por vÍa oral de CD73, con una IC50 de 0,25 nM.

  • GC65293 structure
    GC65293AB-680
    CAS: 2105904-82-1
    Purity: >98.00%

    AB-680 es un inhibidor altamente potente, reversible y selectivo de CD73 (una ectonucleotidasa), con una Ki de 4,9 pM para hCD73, muestra una selectividad >10 000 veces sobre las ectonucleotidasas relacionadas CD39. Actividad antitumoral.

  • GC65470 structure
    GC65470Oleclumab
    CAS: 1803176-05-7
    Purity: >98.00%

    Oleclumab (MEDI9447) es un anticuerpo monoclonal IgG1Λ anti-CD73 humano que inhibe la funciÓn de CD73. Oleclumab tiene actividad antitumoral.

  • GC68344 structure
    GC68344Mupadolimab
    CAS: 2451856-97-4
    Purity: >98%
  • GC68346 structure
    GC68346Uliledlimab
    CAS: 2378407-27-1
    Purity: >98%
  • GC68386 structure
    GC68386CD73-IN-5
    CAS: 2412019-99-7
    Purity: >98%
  • GC69453 structure
    GC69453MethADP triammonium
    Purity: >99.00%

    MethADP (triamonio de adenosina 5'-alfa,beta-metilendifosfato) es un inhibidor de CD73. MethADP se puede utilizar en la investigación de la vía ATP-adenosina.

  • GC79353 structure
    GC793532,4-Dinitrobenzenesulfonic acid
    CAS: 89-02-1
    Purity: >98.00%

    2,4-Dinitrobenzenesulfonic acid (Compound 3) is a ecto-5'-Nucleotidase ( CD73 ) inhibitor with a K i value of 63 μM for human and 144 μM for rat.