GLPBio

CETP

Read More about this category

CETP (cholesteryl ester transfer protein) is a hydrophobic glycoprotein consisting of 476 amino acids residue that, in general, facilitates the transfer of neutral lipids (such as cholesteryl and triglycerides) among lipoprotein particles. The chemical structure of CETP takes on a shape of a boomerang in which a long hydrophobic tunnel with openings at either end allows lipids to be exchanged between donor and acceptor lipoproteins in a non-aqueous phase. Study results suggest that CETP facilitates the transfer of cholesteryl esters from HDL to LDL and VLDL resulting in the lowering of HDL levels and raising of LDL and VDL levels, which might increase the risk of cardiovascular disease.

Products Related to CETP(11)

  • GC13856 structure
    GC13856Dalcetrapib (JTT-705, RO4607381)
    CAS: 211513-37-0
    Purity: >99.00%

    An inhibitor of cholesteryl ester transfer protein

  • GC14061 structure
    GC14061Evacetrapib (LY2484595)
    CAS: 1186486-62-3
    Purity: >99.00%

    A CETP inhibitor

  • GC15848 structure
    GC15848Torcetrapib
    CAS: 262352-17-0
    Purity: >99.00%

    A CETP inhibitor

  • GC17520 structure
    GC17520Anacetrapib (MK-0859)
    CAS: 875446-37-0
    Purity: >99.50%

    A CETP inhibitor

  • GC35657 structure
    GC35657CETP-IN-3
    CAS: 939391-31-8
    Purity: >98%

    CETP-IN-3 (Compuesto 13) es un inhibidor de molécula pequeÑa de la proteÍna de transferencia de éster de colesterol de glicoproteÍna plasmÁtica (CETP), que eleva el HDL-C a través de la inhibiciÓn de CETP.

  • GC37736 structure
    GC37736TAP311
    CAS: 1149362-88-8
    Purity: >98%

    TAP311 es un inhibidor de la proteÍna de transferencia de éster de colesterilo (CETP) con una IC50 de 62 nM.

  • GC38759 structure
    GC38759CP-532623
    CAS: 261947-38-0
    Purity: >98%

    CP-532623 es un inhibidor de la CETP y eleva el nivel de colesterol de las lipoproteÍnas de alta densidad.

  • GC50257 structure
    GC50257BMS 795311
    CAS: 939390-99-5
    Purity: >98%

    BMS 795311 es un inhibidor potente y biodisponible por vía oral de la proteína de transferencia de éster de colesterilo (CETP), con IC50 de 4 nM en un ensayo de proximidad de centelleo basado en enzimas (SPA) y 0,22 μM en un ensayo de plasma completo humano (hWPA), respectivamente.

  • GC68876 structure
    GC68876CKD-519
    CAS: 1402796-27-3
    Purity: >99.00%

    CKD-519 es un inhibidor selectivo y efectivo de la proteína de transferencia de ésteres de colesterol (CETP), que inhibe la transferencia de ésteres de colesterol mediada por CETP en suero humano, con un valor IC50 de 2.3 nM.

  • GC79585 structure
    GC79585UBA6-IN-1
    CAS: 1557137-61-7
    Purity: >99.00%

    UBA6-IN-1 is a UBA6/UBE1L2 inhibitor ( IC 50 ≤50 nM) that acts by reducing the level of squalene epoxidase ( SQLE ).

  • GC81860 structure
    GC81860UBA6-IN-1 hydrochloride
    CAS: 1557138-61-0
    Purity: >98.00%

    UBA6-IN-1 hydrochloride is a UBA6/UBE1L2 inhibitor ( IC 50 ≤50 nM) that acts by reducing the level of squalene epoxidase ( SQLE ).