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CT3 (Synonyms: Cyanotriazole 3)

Catalog No.GC91411 Copy One-Click Copy Product Info

CT3 es un antiparasitario cianotriazol.

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CT3 Chemical Structure

Cas No.: 2403729-27-9

Tamaño Precio Disponibilidad Cantidad
500μg
36,00 $
Disponible
1mg
69,00 $
Disponible
5mg
163,00 $
Disponible

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Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.



Description of CT3

CT3 is a cyanotriazole antiparasitic.1 It is active against T. b. brucei, T. b. gambiense, T. b. rhodesiense, T. cruzi, and L. donovani (EC50s = 180, 31, 57, 78, and 134 nM, respectively). CT3 (4 µM) inhibits nuclear, but not kinetoplastid, DNA replication in the bloodstream form of T. b. brucei. It inhibits T. cruzi topoisomerase II but not human topoisomerase II-α. CT3 (30 mg/kg per day for five days) eradicates T. cruzi in a mouse model of Chagas disease. It also eradicates the T. b. brucei strain STIB975 at stage I and stage II in a mouse model of African trypanosomiasis when administered at a dose of 10 mg/kg for four or seven days, respectively.

Chemical Properties of CT3

Cas No. 2403729-27-9 SDF
Sinónimos Cyanotriazole 3
Formula C19H12F4N6O M.Wt 416.3
Solubility DMF: 25 mg/ml,DMSO: 15 mg/ml,Ethanol: Slightly soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of CT3

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.4021 mL 12.0106 mL 24.0211 mL
5 mM 480.4 μL 2.4021 mL 4.8042 mL
10 mM 240.2 μL 1.2011 mL 2.4021 mL
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In vivo Formulation Calculator (Clear solution) of CT3

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Review for CT3

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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