Cytoskeleton & Motor Proteins

El amiprofos-metilo (BAY-NTN 6867) es un herbicida de amida fosfórica.

BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 uM.

An inhibitor of microtubule polymerization

YK-3-237, un activador de SIRT1, se dirige al mutante p53. YK-3-237 inhibe la proliferaciÓn de células de cÁncer de mama triple negativas.

TN-16 es un potente inhibidor de la polimerizaciÓn de microtÚbulos con IC50 de 0,4-1,7 μM.

Abraxane (Nab-Paclitaxel), a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system.

Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM.

MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK; IC50 = 5.8 nM), a kinase involved in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors.

Colcemid es un inhibidor del citoesqueleto que induce el arresto mitótico en la fase G2/M o el arresto meiótico en la fase de ruptura de vesículas (GVBD) en células de mamíferos u ovocitos, respectivamente.

La 9-(2,2-Dicianovinil)julolidina (9-(2,2-Dicianovinil)julolidina), un rotor molecular y un tinte fluorescente Único, se une a la tubulina y la actina y aumenta drÁsticamente la intensidad de su fluorescencia tras la polimerizaciÓn.

CAY10701 is a 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa and MCF-7 cells (GI50s = 22 and 38 nM, respectively).

16-epi Latrunculin B, first isolated from the Red Sea sponge N.

Sphingosine-1-phosphate (S1P), a bioactive lipid involved in many signaling processes, is irreversibly degraded by the membrane-bound S1P lyase.

(S)-3'-hydroxy Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.

(S)-3'-amino Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.

An inhibitor of tubulin polymerization

(E)-2-Hexadecenal alkyne is an alkyne version of the sphingolipid degradation product (E)-2-hexadecenal that can be used as a click chemistry probe.

(R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin, which is the inactive form of (-)-blebbistatin.

(S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.

Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 μM), a kinase involved in cell division.

Cambendazol es uno de los agentes mÁs efectivos para la terapia de estrongiloidiasis humana y .

Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis.

Phalloidin-AMCA conjugate is a blue fluorophore that specifically labels filamentous actin (F-actin).

Phalloidin-fluorescein conjugate is a green fluorophore that specifically labels filamentous actin (F-actin).