DHFR
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Dihydrofolate reductase (DHFR) is an enzyme that catalyzes the reduction of dihydrofolate (H2F) to tetrahydrofolate (H4F) utilizing nicotinamide adenine dinucleotide phosphate (NADPH) as the hydride (H-) donor, in which the pro-R hydrogen of NADPH is transferred to C6 of the pteridine ring with concomitant protonation at the N5 position. The functional DHFR gene (approximately 30 kb with six exons and five introns) has been identified to encode DHFR enzyme. Human DHFR enzyme is a monomeric protein of 186 amino acids, which is characterized by containing a highly conserved dinucleotide-binding domain consisting of seven parallel and one antiparallel β-strands intercalated by α-helices.
Products Related to DHFR(7)
- GC10405MethotrexateCAS: 59-05-2Purity: >98.00%
Methotrexate es un antimetabolito antifolato que inhibe eficazmente la actividad de la dihidrofolato reductasa (DHFR), con un IC 50 de aproximadamente 7nM.
- GC11610PemetrexedCAS: 150399-23-8Purity: >99.00%
Pemetrexed (also known as pemetrexed disodium) is a novel antifolate antimetabolite targeting multiple enzymes involved in both pyrimidine and purine synthesis.
- GC16333Cycloguanil (hydrochloride)CAS: 152-53-4Purity: >99.50%
El cicloguanil (clorhidrato), el metabolito activo del proguanil, actúa sobre los esquizontes del paludismo en eritrocitos y hepatocitos.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC10405 | Methotrexate | 59-05-2 | >98.00% | |
Methotrexate es un antimetabolito antifolato que inhibe eficazmente la actividad de la dihidrofolato reductasa (DHFR), con un IC 50 de aproximadamente 7nM. | ||||
| GC11610 | Pemetrexed | 150399-23-8 | >99.00% | |
Pemetrexed (also known as pemetrexed disodium) is a novel antifolate antimetabolite targeting multiple enzymes involved in both pyrimidine and purine synthesis. | ||||
| GC12919 | Pralatrexate | 146464-95-1 | >98.00% | |
A dihydrofolate reductase inhibitor | ||||
| GC16333 | Cycloguanil (hydrochloride) | 152-53-4 | >99.50% | |
El cicloguanil (clorhidrato), el metabolito activo del proguanil, actúa sobre los esquizontes del paludismo en eritrocitos y hepatocitos. | ||||
| GC17694 | Pemetrexed disodium hemipenta hydrate | 357166-30-4 | >99.00% | |
| GC17867 | Pyrimethamine | 58-14-0 | >99.50% | |
A dihydrofolate reductase inhibitor | ||||
| GC73335 | DHFR-IN-4 | 2820126-49-4 | >99.00% | |
DHFR-IN-4 es un potente inhibide la didrofolato reductasa (DHFR) con un valor de IC50 de 123 nM. | ||||