Dihydrohonokiol B (Dihydrohonokiol) is an anxiolytic agent. Dihydrohonokiol B can reduce the neurotoxicity induced by amyloid β protein by stimulating the GABA C receptor. Dihydrohonokiol B can be used in the research of neurodegenerative diseases such as Alzheimer's disease [1] [2].
References:
[1]. Esumi T, et al. Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan. Bioorg Med Chem Lett. 2004 May 17;14(10):2621-5.
[2]. Liu B, et al. Anxiolytic agent, dihydrohonokiol-B, recovers amyloid beta protein-induced neurotoxicity in cultured rat hippocampal neurons. Neurosci Lett. 2005 Aug 12-19;384(1-2):44-7.
References:
[1]. Esumi T, et al. Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan. Bioorg Med Chem Lett. 2004 May 17;14(10):2621-5.
[2]. Liu B, et al. Anxiolytic agent, dihydrohonokiol-B, recovers amyloid beta protein-induced neurotoxicity in cultured rat hippocampal neurons. Neurosci Lett. 2005 Aug 12-19;384(1-2):44-7.